# Late menopauze vermindert aortastijfheid in de postmenopauzale periode

*geplaatst 2026-01-12 · Hypertensie · Hypertension · doi https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.26346 · https://hartvaat.nl/2026/01/12/late-menopauze-vermindert-aortastijfheid-in-de-postmenopauzale-periode/*

Een latere menopauze (≥55 jaar) is geassocieerd met een lager cardiovasculair risico dan een normale menopauze (45-54 jaar). Deze studie toont dat late menopauze de aortastijfheid vermindert bij postmenopauzale vrouwen.

## English: Late-Onset Menopause Attenuates Aortic Stiffness in the Postmenopausal Period

This study demonstrates that late-onset menopause attenuates aortic stiffness in postmenopausal women. The vascular protection may partly explain the lower cardiovascular risk associated with later menopause age.

## Abstract (original, from the publication)

Hypertension, Volume 83, Issue 3, Page e26346, March 1, 2026. BACKGROUND:A later age at menopause (≥55 years) is associated with lower cardiovascular disease risk compared with a normal age at menopause (45–54 years) in postmenopausal women (PMW). Aortic stiffening increases cardiovascular disease risk, but the impact of late-onset menopause on aortic stiffness is unknown.METHODS:Total aortic stiffness (carotid-femoral pulse wave velocity [PWVCF]) was measured in 40 late-onset and 86 normal-onset PMW. Structural- and load/blood pressure-dependent PWVCFwere calculated with exponential models; the percent of total PWVCFattributable to each was determined. Elastic modulus was assessed in aortic rings from female C57BL/6 N mice (3–6 months) exposed to 5% PMW serum. Lipidomics and triglyceride-related metabolite exposure of aortas with/without the mitochondrial antioxidant MitoQ identified lipid drivers of mitochondrial reactive oxygen species-related stiffness.RESULTS:PWVCFwas 128 cm/s low

Auteurs: Sanna Darvish

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Bron: Hypertension, https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.26346. Bijgewerkt 2026-07-03T13:24:57Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.