{"id":"ae2c61b3f17f","type":"article","url":"https://hartvaat.nl/2026/01/12/lipide-inhoud-in-verkalkte-plaques-kenmerken-en-respons-op-lage-ldl-c/","title":"Lipide-inhoud in verkalkte plaques: kenmerken en respons op lage LDL-C","title_en":"Lipidic contents within calcified plaques: Characteristics and response to LDL-C<55 mg/dL on multi-modality imaging","category":"cholesterol","category_label":"Cholesterol","professions":["cardioloog"],"tags":["bempedoïnezuur","dyslipidemie","ezetimibe","ldl-cholesterol","lipide-aferese","lipidenverlaging","niet-statine-therapie","pcsk9-remmers","plaquekarakterisatie","yellow-iii"],"journal":"Atherosclerosis","doi":"https://www.atherosclerosis-journal.com/article/S0021-9150(25)01398-X/fulltext","source_url":"https://doi.org/https://www.atherosclerosis-journal.com/article/S0021-9150(25)01398-X/fulltext","authors":["Kentaro Mitsui","Yu Kataoka","Stephen J. Nicholls","Eri Kiyoshige","Kunihiro Nishimura","Rishi Puri","Kota Murai","Kenichiro Sawada","Hideo Matama","Takamasa Iwai","Satoshi Honda","Masashi Fujino","Kazuhiro Nakao","Kensuke Takagi","Shuichi Yoneda","Fumiyuki Otsuka","Kensaku Nishihira","Itaru Takamisawa","Yasuhide Asaumi","Kenichi Tsujita","Teruo Noguchi"],"significance":5,"published":"2026-01-12","source_date":"2026-01-12","image":"","kennis":["https://hartvaat.nl/kennis/lipiden/atherosclerose-pathofysiologie/"],"congress":"","summary_en":"This multimodality imaging study evaluated lipidic contents within calcified coronary plaques and their response to LDL-C lowering below 55 mg/dL. The findings challenge the traditional view of calcified plaques as entirely quiescent atheroma.","created":"2026-07-03T10:25:33Z","updated":"2026-07-03T13:24:57Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Verkalkte plaques werden traditioneel gezien als gevorderde, rustige atherosclerose. Pathologische studies tonen echter lipide-inhoud in verkalkte plaques. Deze studie evalueerde de kenmerken en respons op LDL-C <55 mg/dL met multimodale beeldvorming.","abstract_original":"Calcified plaques have traditionally been regarded as advanced and quiescent atheroma. However, pathological studies indicate lipid content within calcified plaques, suggesting that calcified plaques may harbor active lipidic contents. This study evaluated lipidic plaque content in calcified lesions in vivo using IVUS, OCT and near-infrared spectroscopy (NIRS)."}