{"id":"9dbd8d4e5107","type":"article","url":"https://hartvaat.nl/2026/01/19/neurale-upregulatie-van-sglt2-map17-pdzk1-complex-in-nieren-bij-hartfalen/","title":"Neurale upregulatie van SGLT2-MAP17-PDZK1-complex in nieren bij hartfalen","title_en":"Neural Upregulation of SGLT2-MAP17-PDZK1 Complex in Kidneys of Rats With Heart Failure","category":"hypertensie","category_label":"Hypertensie","professions":["cardioloog","internist"],"tags":[],"journal":"Hypertension","doi":"https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.26077","source_url":"https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.26077","authors":[],"significance":5,"published":"2026-01-19","source_date":"2026-01-19","image":"","kennis":["https://hartvaat.nl/kennis/hypertensie/eindorgaanschade-hypertensie/"],"congress":"","summary_en":"This study reveals neural upregulation of the SGLT2-MAP17-PDZK1 scaffolding protein complex in kidneys during heart failure, providing molecular insight into the relationship between renal sympathetic activation and SGLT2 expression that may explain the efficacy of SGLT2 inhibitors in heart failure.","created":"2026-07-03T10:25:32Z","updated":"2026-07-03T13:24:56Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Congestief hartfalen gaat gepaard met neurohumorale activatie en vochtretentie. Renale denervatie verlicht deze vochtretentie. Dit onderzoek toont neurale upregulatie van het SGLT2-MAP17-PDZK1-complex in de nieren van ratten met hartfalen.","abstract_original":"Hypertension, Volume 83, Issue 4, Page e26077, April 1, 2026. BACKGROUND:Congestive heart failure (CHF) is characterized by the activation of neurohumoral drive concomitant with avid fluid retention. Renal denervation alleviates this fluid retention. SGLT2 (sodium-glucose cotransporter 2) inhibitors have shown remarkable improvement in patients with cardiovascular diseases. We have recently demonstrated a relationship between enhanced renal sympathetic nerve activity and SGLT2 expression as well as function during CHF; however, the precise molecular mechanisms involved in the expression and translocation of SGLT2 and associated scaffolding proteins to the luminal membrane remain to be examined.METHODS:CHF was induced by coronary artery ligation followed by bilateral renal denervation 4 weeks later, in rats. Western blot analysis and immunohistochemistry were performed to evaluate changes in the expression of SGLT2, MAP17 (membrane-associated protein 17), PDZK1 (PDZ domain containing 1)"}