{"id":"4fa5558cd2c8","type":"article","url":"https://hartvaat.nl/2026/01/19/sglt2-remming-behoudt-antibacteriele-respons-van-de-nier-door-complement-c1q-ver/","title":"SGLT2-remming behoudt antibacteriële respons van de nier door complement C1q-verlaging","title_en":"Sodium glucose transporter 2 inhibition maintains kidney antibacterial response by decreasing complement C1q","category":"chronische nierziekte","category_label":"Nierziekte","professions":["apotheker","internist"],"tags":["canagliflozine","sglt2-remmers"],"journal":"Kidney International","doi":"https://www.kidney-international.org/article/S0085-2538(26)00009-8/fulltext","source_url":"https://doi.org/https://www.kidney-international.org/article/S0085-2538(26)00009-8/fulltext","authors":["Georg W. Sendtner","Julia Miranda","Pia Naumann","Maximilian Weiss","Pelin Güls","Ernst Molitor","Uta Scheidt","Axel Schmidt","Kerstin U. Ludwig","Annika Hilger","Ulrich Dobrindt","Thomas Mayrhofer","Christian Kurts","Florian Wagenlehner","Olga Shevshuk","Sibylle von Vietinghoff"],"significance":5,"published":"2026-01-19","source_date":"2026-01-19","image":"","kennis":["https://hartvaat.nl/kennis/nierziekte/sglt2-nierbescherming-mechanisme/","https://hartvaat.nl/kennis/farmacologie/sglt2-remmers-farmacologie/"],"congress":"","summary_en":"This study reveals that SGLT2 inhibition maintains the kidney's antibacterial defence by decreasing complement C1q, explaining why glycosuria from SGLT2 inhibitors does not increase urinary tract infection rates despite promoting bacterial growth conditions.","created":"2026-07-03T10:25:32Z","updated":"2026-07-03T13:24:56Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Glucose bevordert bacteriegroei, maar SGLT2-remmers — die glucoserecuperatie uit urine voorkomen — verhogen het infectierisico niet. Dit onderzoek toont dat SGLT2-remming de antibacteriële nierrespons behoudt door verlaging van complement C1q.","abstract_original":"Glucose promotes bacterial growth. Sodium-glucose transporter 2 inhibition (SGLT2i), which prevents glucose recovery from the urine, is standard therapy in chronic kidney diseases. However, kidney bacterial infection rates did not increase. Here, we investigated possible underlying mechanisms contributing to this effect."}