{"id":"fa7664238ce6","type":"article","url":"https://hartvaat.nl/2026/01/20/multi-omics-onthult-pathogene-rol-van-iga-7-cellen-bij-iga-nefropathie/","title":"Multi-omics onthult pathogene rol van IgA+β7+ cellen bij IgA-nefropathie","title_en":"Multi-omics analyses reveal the pathogenic role of terminal ileum-derived IgA+β7+ cells in IgA nephropathy","category":"chronische nierziekte","category_label":"Nierziekte","professions":["internist"],"tags":["complementremmers","iga-nefropathie"],"journal":"Kidney International","doi":"https://www.kidney-international.org/article/S0085-2538(26)00010-4/fulltext","source_url":"https://doi.org/https://www.kidney-international.org/article/S0085-2538(26)00010-4/fulltext","authors":["Xingzi Liu","Lan Wang","Miaomiao Lin","Niya Jia","Guanyi Liu","Jiawen Peng","Jingyu Wang","Tong Xie","Shaoqing Dang","Jingyi Wu","Xujie Zhou","Lijun Liu","Sufang Shi","Jicheng Lv","Jonathan Barratt","Yuemiao Zhang","Hong Zhang"],"significance":5,"published":"2026-01-20","source_date":"2026-01-20","image":"","kennis":[],"congress":"","summary_en":"Multi-omics analyses revealed the pathogenic role of terminal ileum-derived IgA-positive beta7-positive cells in IgA nephropathy, identifying the mucosal origin of the galactose-deficient IgA1 producing plasma cells central to disease pathogenesis.","created":"2026-07-03T10:25:32Z","updated":"2026-07-03T13:24:56Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Galactosedeficiënt IgA1 speelt een sleutelrol bij IgA-nefropathie, maar de locatie van de verantwoordelijke plasmacellen was onbekend. Multi-omics analyses onthullen de pathogene rol van terminale ileum-afkomstige IgA+β7+ cellen.","abstract_original":"Galactose-deficient IgA1 (Gd-IgA1) plays a key role in IgA nephropathy (IgAN), but the location of the plasma cells responsible for its production remain unknown."}