{"id":"1d3516ee2b05","type":"article","url":"https://hartvaat.nl/2026/01/21/body-roundness-index-en-mortaliteit-bij-hemodialysepatienten/","title":"Body Roundness Index en mortaliteit bij hemodialysepatiënten","title_en":"Association between body roundness index and all-cause and cardiovascular disease mortality in maintenance hemodialysis patients: evidence from a prospective cohort study in Southern China.","category":"chronische nierziekte","category_label":"Nierziekte","professions":["internist"],"tags":[],"journal":"Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association","doi":"10.1093/ndt/gfag006","source_url":"https://doi.org/10.1093/ndt/gfag006","authors":["Yu Wang","Liheng Zhu","Yaya Yang","Ziyang You","Zhiqiang Peng","Shenglin Yang","Yongxin Lu","Yanhong Zhao","Yaozhong Kong","Qijun Wan","Yumin Li","Sheng Huang","Yan Liu","Aiqun Liu","Fanna Liu","Min Liang"],"significance":5,"published":"2026-01-21","source_date":"2026-01-21","image":"","kennis":["https://hartvaat.nl/kennis/nierziekte/nierziekte-en-cardiovasculair-risico/","https://hartvaat.nl/kennis/cardiometabool/diabetes-en-cardiovasculair-risico/"],"congress":"","summary_en":"A prospective cohort study from Southern China investigated the association between the Body Roundness Index and all-cause and cardiovascular mortality in maintenance haemodialysis patients. The anthropometric index, which predicts body fat and visceral adipose tissue, was associated with mortality outcomes in this population.","created":"2026-07-03T10:25:08Z","updated":"2026-07-03T13:24:35Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"De Body Roundness Index (BRI) voorspelt lichaamsvet en visceraal vetweefsel, maar de relatie met overleving bij hemodialysepatiënten was onbekend. Deze prospectieve cohortstudie uit Zuid-China onderzocht het verband tussen BRI en totale en cardiovasculaire mortaliteit bij patiënten in onderhoudsdialyse.","abstract_original":"BACKGROUND: The Body Roundness Index (BRI) is an anthropometric index for predicting the proportion of body fat and visceral adipose tissue, yet its association with survival in maintenance hemodialysis (MHD) patients remains unclear. Therefore, this study aims to investigate the relationship between BRI and the risk of all-cause and cardiovascular disease (CVD) mortality in MHD patients. METHODS: This is a secondary analysis of a multicenter prospective cohort study included 1034 MHD patients aged over 18 years. Participants were stratified into groups by BRI quartile. Cox models and multivariable-adjusted restricted cubic spline (RCS) were performed to analyze the association of BRI with all-cause and CVD mortality after adjusting for confounding factors. C-statistic, net reclassification improvement (NRI) and integrated discrimination improvement (IDI) were utilized to evaluate the predictive performance of BRI. RESULTS: During a median follow-up of 4.4 years, we observed a total of 548 all-cause deaths and 297 CVD deaths. The analysis revealed significant positive associations between BRI and both all-cause and CVD mortality. After adjusting for confounding factors, each 1-standard deviation (SD) increase in BRI was associated with a 27% higher risk of all-cause mortality (HR = 1.27,95% CI:1.22, 1.42) and a corresponding 40% increased risk of CVD mortality (HR = 1.40, 95% CI:1.18, 1.67). In the combined analysis with BMI, individuals with normal BMI (<24.0 kg/m²) but elevated BRI (≥3.99) exhibited the highest risk of all-cause mortality, a trend that was similarly observed for CVD mortality. Moreover, the model integrating BRI with BMI demonstrated superior predictive performance compared to the baseline model and models with either variable alone, as assessed by the C-statistic, NRI, and IDI. CONCLUSION: High BRI independently predicted all-cause and CVD mortality in MHD patients. The combined assessment of BRI and BMI facilitates the early identification of high-risk patients and may enable more personalized patient management."}