# Finerenon verbetert albuminurie via MR-TRPC-signalering bij diabetische nierziekte

*geplaatst 2026-01-22 · Hypertensie · Hypertension · doi https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.25739 · https://hartvaat.nl/2026/01/22/finerenon-verbetert-albuminurie-via-mr-trpc-signalering-bij-diabetische-nierziek/*

Recente studies bevestigen de beschermende effecten van niet-steroïdale MR-antagonisten bij diabetische nierziekte. Dit onderzoek onthult dat finerenon de albuminurie verbetert via MR-TRPC-signalering, wat het fysiologische mechanisme verduidelijkt.

## English: Finerenone Improves Albuminuria via MR-TRPC Signaling in Diabetic Kidney Disease

This study reveals that finerenone improves albuminuria in diabetic kidney disease through the mineralocorticoid receptor-TRPC signalling pathway, protecting podocytes by limiting excessive calcium influx via TRPC5 channels.

## Abstract (original, from the publication)

Hypertension, Volume 83, Issue 4, Page e25739, April 1, 2026. BACKGROUND:Recent studies have confirmed the protective effects of nonsteroidal MR (mineralocorticoid receptor) antagonists in diabetic kidney disease. However, the physiological mechanisms underlying their albuminuria-reducing effects remain incompletely defined. We hypothesized that inhibition of the MR could protect podocytes by limiting excessive calcium influx via TRPC (transient receptor potential canonical) 5, thereby reducing albuminuria.METHODS:We evaluated the effects of the nonsteroidal MR antagonist finerenone on albuminuria, podocyte morphology, and glomerular function in diabetic mice. Reactive oxygen species generation and single-nephron glomerular filtration rate were analyzed using in vivo imaging. Cultured podocytes were used to assess MR-TRPC5 signaling through measurements of Sgk1 (serum- and glucocorticoid-regulated kinase 1) and TRPC5 expression, intracellular calcium, and actin cytoskeletal organizatio

Auteurs: Tsukasa Iwakura

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Bron: Hypertension, https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.25739. Bijgewerkt 2026-07-03T13:24:55Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.