{"id":"f44a9b706a29","type":"article","url":"https://hartvaat.nl/2026/01/22/microbiele-metaboliet-4eps-remt-at1r-en-verlaagt-bloeddruk-en-aorta-aneurysmavor/","title":"Microbiële metaboliet 4EPS remt AT1R en verlaagt bloeddruk en aorta-aneurysmavorming","title_en":"Microbial Metabolite 4EPS Inhibits AT1R to Reduce Blood Pressure and Aortic Aneurysm Outcome","category":"hypertensie","category_label":"Hypertensie","professions":["internist"],"tags":[],"journal":"Hypertension","doi":"https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.25364","source_url":"https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.25364","authors":[],"significance":5,"published":"2026-01-22","source_date":"2026-01-22","image":"","kennis":["https://hartvaat.nl/kennis/hypertensie/cardiovasculaire-risicoschatting-score2/","https://hartvaat.nl/kennis/nierziekte/nierziekte-en-cardiovasculair-risico/"],"congress":"","summary_en":"This study demonstrates that the gut microbial metabolite 4-ethylphenylsulfate directly inhibits the angiotensin II type 1 receptor, reducing blood pressure and aortic aneurysm formation. The finding reveals a novel microbiome-cardiovascular signalling axis.","created":"2026-07-03T10:25:31Z","updated":"2026-07-03T13:24:55Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"4-Ethylfenylsulfaat (4EPS), een darmmicrobiële metaboliet van het aminozuur tyrosine, was geassocieerd met cardiovasculaire en renale uitkomsten. Dit onderzoek toont dat 4EPS de angiotensine II type 1-receptor (AT1R) remt, wat de bloeddruk verlaagt.","abstract_original":"Hypertension, Volume 83, Issue 3, Page e25364, March 1, 2026. BACKGROUND:Plasma accumulation of the gut microbial metabolite 4-ethylphenylsulfate (4EPS), derived from dietary amino acid, tyrosine, has been associated with cardiovascular, renal, metabolic, and neurological disorders. AngII (angiotensin II) infusion increases circulating 4EPS in mice, suggesting a potential mechanistic role. We hypothesized that 4EPS modulates AngII-regulated pathophysiology and disease progression by directly inhibiting AT1R (angiotensin II type 1 receptor).METHODS:This hypothesis was tested by combining AT1R pharmacology, cell signaling assays, ex vivo vascular studies, an AngII-induced aortic aneurysm growth model, and plasma proteomics analysis.RESULTS:in vitro, 4EPS reduced the binding of both AngII and the antagonist candesartan to AT1R and suppressed AngII-induced calcium signaling. Ex vivo, 4EPS attenuated AngII-mediated vasoconstriction. In vivo, high-fat diet–fed ApoE-null mice coinfused with A"}