# Nieuw ratmodel voor chronisch trombo-embolische pulmonale hypertensie

*geplaatst 2026-01-22 · Hypertensie · Hypertension · doi https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.25589 · https://hartvaat.nl/2026/01/22/nieuw-ratmodel-voor-chronisch-trombo-embolische-pulmonale-hypertensie/*

Chronisch trombo-embolische pulmonale hypertensie wordt gekenmerkt door proximale pulmonale arterie-obstructie en distale microvasculopathie. Dit onderzoek ontwikkelde een nieuw ratmodel en identificeerde Sell-Podxl als potentiële regulatoren.

## English: Development and Characterization of a Novel Chronic Thromboembolic Pulmonary Hypertension Rat Model: Identifying Sell-Podxl as Potential Regulators

This study developed a novel chronic thromboembolic pulmonary hypertension rat model using gelatin sponge combined with SU5416 and identified Sell-Podxl as potential regulators of the dual-compartment pulmonary vascular remodelling.

## Abstract (original, from the publication)

Hypertension, Volume 83, Issue 3, Page e25589, March 1, 2026. BACKGROUND:Chronic thromboembolic pulmonary hypertension is characterized by proximal pulmonary artery obstruction and distal microvasculopathy. However, the mechanisms driving this dual-compartment pulmonary vascular remodeling remain unclear.METHODS:Male Sprague-Dawley rats were injected with gelatin sponge combined with SU5416 as a secondary insult. Hemodynamics, echocardiography, and pulmonary vascular remodeling were evaluated to investigate the development of chronic thromboembolic pulmonary hypertension. Single-cell RNA sequencing of rat lung tissue was conducted to elucidate the molecular mechanisms underlying pulmonary vascular remodeling. The results were validated by immunofluorescence and cell-based experiments.RESULTS:The optimal size range of gelatin sponge for large pulmonary artery obstruction was 710 to 1000 µm, which synergized with a low dose of SU5416 (10 mg/kg) to induce significant increases in right ve

Auteurs: Jixiang Liu

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Bron: Hypertension, https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.25589. Bijgewerkt 2026-07-03T18:38:16Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.