{"id":"36e020b14540","type":"article","url":"https://hartvaat.nl/2026/01/23/cellulaire-senescentie-als-therapeutisch-doelwit-bij-diabetische-nierziekte/","title":"Cellulaire senescentie als therapeutisch doelwit bij diabetische nierziekte","title_en":"Targeting cellular senescence in diabetic kidney disease: potential of regenerative, cell-based therapies and other senotherapeutic approaches","category":"chronische nierziekte","category_label":"Nierziekte","professions":["internist"],"tags":["anemie-ckd","chronische-nierziekte","diabetes-en-hart","diabetische-nefropathie","fidelio-dkd","figaro-dkd","ijzertekort","soul-trial"],"journal":"Kidney International","doi":"https://www.kidney-international.org/article/S0085-2538(26)00054-2/fulltext","source_url":"https://doi.org/https://www.kidney-international.org/article/S0085-2538(26)00054-2/fulltext","authors":["Helly A. Patel","Jiaxuan Wang","Caroline J. Zinn","Maya Learmonth","Xiaohui Bian","Diana Jurk","Lilach O. Lerman","Joy Wolfram","LaTonya J. Hickson"],"significance":5,"published":"2026-01-23","source_date":"2026-01-23","image":"","kennis":["https://hartvaat.nl/kennis/cardiometabool/diabetes-en-cardiovasculair-risico/","https://hartvaat.nl/kennis/nierziekte/diabetische-nefropathie/"],"congress":"","summary_en":"This review discusses the potential of regenerative cell-based therapies and senotherapeutic approaches targeting cellular senescence in diabetic kidney disease. Addressing senescence-driven chronic inflammation may overcome treatment resistance in patients who progress despite optimal therapy.","created":"2026-07-03T10:25:30Z","updated":"2026-07-03T13:24:55Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Diabetische nierziekte is de belangrijkste oorzaak van CKD wereldwijd. Ondanks moderne behandelingen vorderen veel patiënten naar nierfalen. Dit overzicht bespreekt het potentieel van regeneratieve celtherapieën en senotherapeutische benaderingen gericht op cellulaire senescentie.","abstract_original":"Diabetic kidney disease (DKD) is the primary cause of chronic kidney disease globally. Although modern treatments can slow the progression of DKD, a substantial number of individuals still advance to kidney failure each year, attributed to complex, multifactorial pathophysiological processes that confer treatment resistance. Cellular senescence, an irreversible state of cell cycle arrest, has emerged as a recognized driver of DKD pathogenesis, which propagates chronic inflammation, leading to tissue damage."}