{"id":"0e64dcabc9f3","type":"article","url":"https://hartvaat.nl/2026/01/26/isolinderalacton-remt-nlrp3-inflammasoomactivatie-bij-atherosclerose/","title":"Isolinderalacton remt NLRP3-inflammasoomactivatie bij atherosclerose","title_en":"Isolinderalactone alleviates atherosclerosis by inhibiting NLRP3 inflammasome activation and inflammatory response in macrophages","category":"cholesterol","category_label":"Cholesterol","professions":["cardioloog"],"tags":["atherosclerose","inflammatie"],"journal":"Atherosclerosis","doi":"https://www.atherosclerosis-journal.com/article/S0021-9150(26)00014-6/fulltext","source_url":"https://doi.org/https://www.atherosclerosis-journal.com/article/S0021-9150(26)00014-6/fulltext","authors":["Jingjing Shao","Haowen Xu","Fangmin Ning","Leiyu Xu","Weifeng Li","Yong Xu","Zhe Wang","Haiyi Chen","Binglu Shi","Ying Kong","Aleksandr V. Samorodov","Wan Gan","Yi Wang"],"significance":3,"published":"2026-01-26","source_date":"2026-01-26","image":"","kennis":["https://hartvaat.nl/kennis/preventie/psychosociale-risicofactoren-hart/"],"congress":"","summary_en":"This study shows that isolinderalactone, a sesquiterpene compound from Lindera aggregata, alleviates atherosclerosis by inhibiting NLRP3 inflammasome activation and the inflammatory response in macrophages.","created":"2026-07-03T10:25:30Z","updated":"2026-07-03T13:24:54Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Atherosclerotische hart- en vaatziekten zijn een belangrijke doodsoorzaak. Isolinderalacton, een sesquiterpeenverbinding uit Lindera aggregata, remt het NLRP3-inflammasoom en de inflammatoire respons in macrofagen, wat een nieuw therapeutisch aangrijpingspunt biedt.","abstract_original":"Atherosclerotic cardiovascular disease is a leading cause of morbidity and mortality worldwide, and an urgent need exists to discover new therapeutic strategies. Isolinderalactone (ISO) is a sesquiterpene compound derived from the Lindera aggregata root with significant anti-inflammatory effects. Given that atherosclerosis (AS) is a chronic inflammatory condition, the efficacy and mechanism of ISO on atherosclerotic disease are still unclear."}