{"id":"f17cb9889784","type":"article","url":"https://hartvaat.nl/2026/01/26/zittende-zoutbelastingstest-voor-lateralisatie-van-primair-aldosteronisme/","title":"Zittende zoutbelastingstest voor lateralisatie van primair aldosteronisme","title_en":"Seated Saline Suppression Test for Lateralizing Primary Aldosteronism","category":"hypertensie","category_label":"Hypertensie","professions":["cardioloog","internist"],"tags":[],"journal":"Hypertension","doi":"https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.26008","source_url":"https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.26008","authors":[],"significance":6,"published":"2026-01-26","source_date":"2026-01-26","image":"","kennis":["https://hartvaat.nl/kennis/nierziekte/nierziekte-en-cardiovasculair-risico/","https://hartvaat.nl/kennis/nierziekte/nsaids-en-nierziekte/"],"congress":"","summary_en":"This blinded clinical trial evaluated a seated saline suppression test for lateralizing primary aldosteronism, testing a simplified confirmatory approach for identifying surgical candidates in PA management.","created":"2026-07-03T10:25:30Z","updated":"2026-07-03T13:24:54Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Het nut van bevestigend onderzoek om lateraliserend primair aldosteronisme te identificeren is onzeker. Deze geblindeerde klinische trial onderzocht de zittende zoutbelastingstest (SSST) bij patiënten met hoog-risicokenmerken voor primair aldosteronisme.","abstract_original":"Hypertension, Volume 83, Issue 5, Page e26008, May 1, 2026. BACKGROUND:Confirmatory testing to identify lateralizing primary aldosteronism (PA) is of uncertain benefit.METHODS:Blinded clinical trial where patients with high-risk features for PA underwent the seated saline suppression test (SSST). All patients received adrenal vein sampling, where lateralization was defined by an aldosterone/cortisol ratio ≥3:1 comparing the dominant versus the nondominant sides. The primary outcome was the overall diagnostic accuracy of the SSST in identifying lateralizing PA using postinfusion aldosterone concentrations of ≥140 pmol/L (5.0 ng/dL) and ≥280 pmol/L (10.1 ng/dL) with immunoassay, and ≥162 pmol/L (5.8 ng/dL) with liquid chromatography/tandem mass spectrometry.RESULTS:A total of 160 patients completed the trial. Lateralizing PA was diagnosed in 98 patients (61.3%). The overall diagnostic accuracy of the SSST using an aldosterone cutoff of ≥140 pmol/L (5.0 ng/dL) and ≥280 pmol/L (10.1 ng/dL)"}