{"id":"db0d1a08aefd","type":"article","url":"https://hartvaat.nl/2026/02/01/gedeeld-gennetwerk-verklaart-de-wisselwerking-tussen-atriumfibrilleren-en-hartfa/","title":"Gedeeld gennetwerk verklaart de wisselwerking tussen atriumfibrilleren en hartfalen","title_en":"A reduced TBX5-dependent gene regulatory network links atrial fibrillation and heart failure.","category":"atriumfibrilleren","category_label":"Atriumfibrilleren","professions":["cardioloog"],"tags":["acuut-hartfalen","atriale-cardiomyopathie","hfpef","hfref","laminopathie","ventrikelfibrilleren"],"journal":"Nature cardiovascular research","doi":"10.1038/s44161-025-00775-2","source_url":"https://doi.org/10.1038/s44161-025-00775-2","authors":["Sonja Lazarevic","Carlos Perez-Cervantes","Zhezhen Wang","Kaitlyn M Shen","Margaret Gadek","Junhua Xiao","Naoko Yamaguchi","Johnathon M Hall","Yildiz Koca","Douglas J Chapski","Manuel Rosa-Garrido","Marcello Rubino","Rangarajan D Nadadur","Timothy A McKinsey","Thomas M Vondriska","Alexander J Ruthenburg","Sebastian Pott","David S Park","Ivan P Moskowitz"],"significance":7,"published":"2026-02-01","source_date":"2026-02-01","image":"https://hartvaat.nl/global/img/65747e238e62.webp","kennis":["https://hartvaat.nl/kennis/atriumfibrilleren/af-en-hartfalen/","https://hartvaat.nl/kennis/atriumfibrilleren/elektrisch-remodellering-atrium/"],"congress":"","summary_en":"This Nature Cardiovascular Research study revealed that atrial fibrillation and heart failure share a common TBX5-dependent gene regulatory network, providing molecular evidence for the bidirectional relationship between these two conditions.","created":"2026-07-03T10:25:00Z","updated":"2026-07-03T18:38:10Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Onderzoek in Nature Cardiovascular Research onthult dat atriumfibrilleren en hartfalen een gemeenschappelijk TBX5-afhankelijk genregulatienetwerk delen. Bij beide aandoeningen is de expressie van TBX5 in het atrium verlaagd, wat leidt tot verstoring van beschermende genen en activatie van fibroseroutes.","abstract_original":"Atrial fibrillation (AF) and heart failure (HF) frequently coexist and worsen one another's outcomes. To investigate shared molecular mechanisms, we compared atrial gene regulatory networks (GRNs) in the mouse Tbx5 conditional knockout (Tbx5 cKO) AF model and the transverse aortic constriction (TAC) HF model. Here we show highly correlated changes in atrial transcriptional and genomic profiles, including downregulated atrial Tbx5 expression in both mouse and human HF. More than 100 transcription factor genes were coordinately dysregulated in the atria of the Tbx5 cKO and TAC models. The wild-type atrial TBX5-driven GRN, including Klf15, a repressor of cardiomyocyte hypertrophy, was disrupted in Tbx5 cKO and TAC models. Conversely, a disease-specific network featuring Sox9 emerged in activated fibroblasts of Tbx5 cKO and TAC models. Our results identify coordinated disruption of TBX5-dependent atrial gene regulation in AF and HF, suggesting that a shared genomic injury response may underlie the reciprocal risk between these conditions."}