{"id":"898c4fd1e35a","type":"article","url":"https://hartvaat.nl/2026/02/01/klonale-hematopoese-en-incident-hartfalen/","title":"Klonale hematopoëse en incident hartfalen","title_en":"Clonal Hematopoiesis and Incident Heart Failure","category":"hartfalen","category_label":"Hartfalen","professions":["cardioloog","internist"],"tags":["ijzersuppletie"],"journal":"JAMA Cardiology","doi":"https://jamanetwork.com/journals/jamacardiology/fullarticle/2841165","source_url":"https://doi.org/https://jamanetwork.com/journals/jamacardiology/fullarticle/2841165","authors":[],"significance":7,"published":"2026-02-01","source_date":"2026-02-01","image":"","kennis":[],"congress":"","summary_en":"This cohort study investigated the association between specific clonal hematopoiesis (CHIP) driver gene subtypes and incident heart failure, exploring a novel genetic pathway linking somatic mutations in hematopoietic stem cells to cardiac disease.","created":"2026-07-03T10:25:29Z","updated":"2026-07-03T13:24:53Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Cohortstudie naar het verband tussen specifieke CHIP-driver-gensubtypes en incident hartfalen, en of CHIP-geassocieerde comorbiditeiten deze associatie mediëren.","abstract_original":"This cohort study investigates the association between specific clonal hematopoiesis of indeterminant potential (CHIP) driver gene subtypes and incident heart failure and if CHIP-associated comorbidities mediate this association."}