{"id":"88c716874153","type":"article","url":"https://hartvaat.nl/2026/02/03/geslachtsverschillen-bij-patienten-met-gevorderd-hartfalen/","title":"Geslachtsverschillen bij patiënten met gevorderd hartfalen","title_en":"Sex differences in patients with advanced heart failure: an analysis of the HELP-HF registry.","category":"hartfalen","category_label":"Hartfalen","professions":["cardioloog"],"tags":["bisoprolol","step-hfpef"],"journal":"ESC heart failure","doi":"10.1093/eschf/xvag004","source_url":"https://doi.org/10.1093/eschf/xvag004","authors":["Mauro Riccardi","Chiara Tedino","Mauro Chiarito","Davide Stolfo","Luca Baldetti","Daniela Tomasoni","Riccardo Maria Inciardi","Marianna Adamo","Alessandro Villaschi","Ferdinando Loiacono","Marta Maccallini","Gaia Gasparini","Stefano Contessi","Daniele Cocianni","Maria Perotto","Giuseppe Barone","Marco Merlo","Alberto Maria Cappelletti","Gianfranco Sinagra","Daniela Pini","Marco Metra","Matteo Pagnesi","Carlo Mario Lombardi"],"significance":6,"published":"2026-02-03","source_date":"2026-02-03","image":"","kennis":[],"congress":"","summary_en":"This HELP-HF registry analysis revealed important sex differences in advanced heart failure, showing that women are referred later and less likely to receive advanced therapies including mechanical support and transplantation.","created":"2026-07-03T10:25:00Z","updated":"2026-07-03T18:38:10Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Een analyse van de HELP-HF database onthult belangrijke geslachtsverschillen bij patiënten met gevorderd hartfalen. Vrouwen worden later doorverwezen, ontvangen minder vaak device-therapie en hebben een ander verloop dan mannen, ondanks vergelijkbare ziekte-ernst.","abstract_original":"INTRODUCTION: Sex differences are reported in patients with heart failure (HF), but gaps remain in clinical practice and evidence, in particular, in those with advanced HF. METHODS: The HELP-HF registry enrolled consecutive patients with HF and at least one high-risk 'I NEED HELP' marker, evaluated at four Italian centres between 1 January 2020 and 30 November 2021. Patients' characteristics and outcomes were compared in men vs women. The primary endpoint was the composite of all-cause mortality or first HF hospitalization. RESULTS: A total of 1149 patients were included (mean age 75.1 ± 11.5 years, median left ventricular ejection fraction 35%). Among them, 773 patients (67.3%) were males. Males were younger, had more cardiovascular diseases and a lower left ventricular ejection fraction (32%, [interquartile range 25-45] vs 45% [interquartile range 30-55]), while females showed a higher prevalence of non-cardiac conditions, neurocognitive and depressive disorders. The 1-year rate of the primary composite endpoint was 43.2% in males and 43.1% in females (log-rank P = .857). Multivariable analysis confirmed the lack of a significant impact of sex on the primary endpoint (adjusted hazard ratio 1.03, 95% confidence interval 0.85-1.27, P = .740). No significant differences were also observed in men vs women for the individual endpoints. CONCLUSIONS: In our registry enrolling patients with markers of advanced HF, despite differences in clinical and echocardiographic characteristics, no sex-related differences in clinical outcomes were observed."}