# Lichamelijke activiteit en risico op complicaties bij atriumfibrilleren

*geplaatst 2026-03-06 · Atriumfibrilleren · Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · doi 10.1093/europace/euag032 · https://hartvaat.nl/2026/02/03/lichamelijke-activiteit-en-risico-op-complicaties-bij-atriumfibrilleren/*

Een post-hoc analyse van twee grote registraties (Europa en Azië-Pacific), gepubliceerd in Europace, laat zien dat lichamelijk actieve AF-patiënten (≥3 uur/week) een lager risico hebben op overlijden en ernstige cardiovasculaire events. De beschermende associatie geldt voor zowel Europese als Aziatische patiënten.

## English: Physical activity and risk of adverse events in atrial fibrillation: evidence from European and Asian cohorts.

This post-hoc analysis of European and Asian-Pacific AF registries showed that physical activity levels are associated with different clinical characteristics and outcomes in AF patients, supporting exercise recommendations across diverse populations.

## Abstract (original, from the publication)

AIMS: To evaluate differences in clinical characteristics and outcomes based on physical activity levels in patients with atrial fibrillation (AF), comparing Europeans and Asians. METHODS AND RESULTS: Post-hoc analysis of two prospective registries from Europe and the Asia-Pacific. Patients were classified as inactive (no exercise or <3 h/week) or active (≥3 h/week). The primary outcome was a composite of all-cause death and major adverse cardiovascular events (MACE). Secondary outcomes included all-cause death, MACE, major bleeding, individual MACE components. Cox model estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for outcomes. Subgroup analyses were performed by clinically relevant variables and enrolment setting. Of 13 126 participants (69 ± 12 years; 39% female), 3639 (28%) were physically active and 9487 (72%) physically inactive. Across both groups, Asians had lower odds of obesity, symptomatic AF and heart failure, but higher odds of cardiovascular risk factors than Europeans. After a median follow-up of 514 days, physically active AF patients had a lower risk of composite outcome (HR 0.66, 95%CI 0.56-0.78), all-cause death (HR 0.52, 95%CI 0.42-0.65), MACE (HR 0.80, 95%CI 0.65-0.99), cardiovascular death (HR 0.60, 95%CI 0.42-0.86), with no significant differences between Europeans and Asians (pinteraction for composite outcome = 0.298). The risk of the composite outcome decreased progressively with increasing levels of physical activity, with no significant differences between Europeans and Asians (pinteraction = 0.845). CONCLUSION: In patients with AF, self-reported physical activity is associated with a lower risk of adverse events, consistently across Europe and Asia. Physical activity may represent a component of a lower-risk clinical profile in AF.

Auteurs: Michele Rossi, Tommaso Bucci, Enrico Tartaglia, Amir Askarinejad, Steven Ho Man Lam, Andrea Galeazzo Rigutini, Claudio Ferri, Giuseppe Boriani, Hung-Fat Tse, Tze-Fan Chao, Gregory Y H Lip

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Bron: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, https://doi.org/10.1093/europace/euag032. Bijgewerkt 2026-07-03T18:39:26Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.