{"id":"ba49c9cee76d","type":"article","url":"https://hartvaat.nl/2026/02/04/bacteriele-extracellulaire-vesikels-reguleren-bloeddruk-via-microbiota-gastheer-/","title":"Bacteriële extracellulaire vesikels reguleren bloeddruk via microbiota-gastheer-communicatie","title_en":"Bacterial Extracellular Vesicles Mediate Microbiota-Host Communication to Regulate Blood Pressure in Male Rats","category":"hypertensie","category_label":"Hypertensie","professions":["internist"],"tags":["microbioom"],"journal":"Hypertension","doi":"https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.25962","source_url":"https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.25962","authors":["Huanan Shi"],"significance":4,"published":"2026-02-04","source_date":"2026-02-04","image":"","kennis":["https://hartvaat.nl/kennis/hypertensie/ace-remmers-hypertensie/","https://hartvaat.nl/kennis/hypertensie/alfa-blokkers-hypertensie/"],"congress":"","summary_en":"This study demonstrates that bacterial extracellular vesicles from the gut microbiota reach the circulation and modulate blood pressure in spontaneously hypertensive stroke-prone rats, revealing a novel microbiota-host communication pathway in hypertension.","created":"2026-07-03T10:25:26Z","updated":"2026-07-03T13:24:51Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Veranderde darmmicrobiota-samenstelling is betrokken bij hypertensie-ontwikkeling. Deze studie toont aan dat bacteriële extracellulaire vesikels de bloedbaan bereiken, perifere weefsels beïnvloeden en de bloeddruk moduleren bij mannelijke ratten.","abstract_original":"Hypertension, Volume 83, Issue 4, Page e25962, April 1, 2026. BACKGROUND:Altered gut microbiota composition has been implicated in the development of hypertension. Evidence suggests bacterial products and metabolites can enter circulation, act on peripheral tissues, and modulate blood pressure (BP). We identified extracellular vesicles (EVs) of bacterial origin (bacterial extracellular vesicles [bEVs]) in the circulation of spontaneously hypertensive stroke–prone rats (SHRSP). We hypothesized that bEVs mediate communication between microbiota and the host, and that bEVs from SHRSP microbiota contain unique cargo that promotes hypertension.METHODS:EVs were isolated from plasma and cecal content of SHRSP and Wistar-Kyoto (WKY) rats. Multiomics analysis, including 16S rRNA sequencing, small RNA sequencing, lipidomics, and proteomics were performed to assess the cargo of bEVs. BEVs from WKY and SHRSP were transplanted by oral gavage to WKY and SHRSP recipients, and the effects on BP and sy"}