{"id":"4c3106b7fb0d","type":"article","url":"https://hartvaat.nl/2026/02/04/endotheliaal-lrrc8c-reguleert-vasculaire-reactiviteit-en-bloeddruk/","title":"Endotheliaal LRRC8C reguleert vasculaire reactiviteit en bloeddruk","title_en":"Endothelial LRRC8C Associates With LRRC8A and LRRC8B to Regulate Vascular Reactivity and Blood Pressure","category":"hypertensie","category_label":"Hypertensie","professions":["internist"],"tags":["endotheel"],"journal":"Hypertension","doi":"https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.25889","source_url":"https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.25889","authors":["Qiujun Yu"],"significance":4,"published":"2026-02-04","source_date":"2026-02-04","image":"","kennis":[],"congress":"","summary_en":"This study identifies LRRC8C as a partner subunit of the mechanoresponsive endothelial LRRC8 complex, working with LRRC8A and LRRC8B to regulate vascular reactivity and blood pressure through endothelial mechanosensing.","created":"2026-07-03T10:25:26Z","updated":"2026-07-03T13:24:51Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Endotheliale mechanosensing is essentieel voor de regulatie van vaattonus. LRRC8A was eerder geïdentificeerd als kernsubunit van het LRRC8-complex. Dit onderzoek toont dat LRRC8C samenwerkt met LRRC8A en LRRC8B om vasculaire reactiviteit en bloeddruk te reguleren.","abstract_original":"Hypertension, Volume 83, Issue 4, Page e25889, April 1, 2026. BACKGROUND:Endothelial mechanosensing is essential for controlling vascular tone. LRRC8A (leucine-rich repeat-containing protein 8A) was previously identified as a core subunit of the mechanoresponsive LRRC8 complex, functionally encoding the endothelial volume regulatory anion channel and regulating vascular function. This study aims to identify the molecular identity of the endothelial LRRC8 complex and its function in vascular reactivity and blood pressure control.METHODS:We generated germline epitope-taggedLrrc8a-3xFlag knock-in mice and endothelium-specificLrrc8a-3xFlag overexpression mice to permit LRRC8A and LRRC8C immunoprecipitation and define LRRC8 subunit interactions. We combined in vivo and in vitro loss-of-function models, electrophysiology, immunoblotting, and pressure myography of third-order mesenteric arteries to examine the contributions of individual LRRC8A/B/C subunits to vascular function and underlying"}