{"id":"a32c4a0c324d","type":"article","url":"https://hartvaat.nl/2026/02/04/verlies-van-ror2-tyrosinekinase-veroorzaakt-endotheeldisfunctie-bij-pah/","title":"Verlies van ROR2-tyrosinekinase veroorzaakt endotheeldisfunctie bij PAH","title_en":"Loss of ROR2 Tyrosine Kinase Receptor Is Associated With Endothelial Dysfunction in PAH via Inappropriate Integrin β1 Activation","category":"hypertensie","category_label":"Hypertensie","professions":["cardioloog"],"tags":["endotheel"],"journal":"Hypertension","doi":"https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.25881","source_url":"https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.25881","authors":["Ankita Mitra"],"significance":5,"published":"2026-02-04","source_date":"2026-02-04","image":"","kennis":[],"congress":"","summary_en":"This study reveals that loss of the ROR2 tyrosine kinase receptor causes endothelial dysfunction in pulmonary arterial hypertension through inappropriate integrin beta1 activation, identifying a novel Wnt signalling pathway in PAH pathogenesis.","created":"2026-07-03T10:25:26Z","updated":"2026-07-03T13:24:51Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Endotheeldisfunctie is een kernkenmerk van pulmonale arteriële hypertensie. Eerdere studies toonden verlaagde Wnt7a-expressie. Dit onderzoek onthult dat verlies van de ROR2-tyrosinekinasereceptor leidt tot ongepaste integrine-β1-activatie en endotheeldisfunctie bij PAH.","abstract_original":"Hypertension, Volume 83, Issue 4, Page e25881, April 1, 2026. BACKGROUND:Endothelial dysfunction is a key feature of pulmonary arterial hypertension (PAH). Previously, we demonstrated decreased Wnt7a transcript levels, causing reduced angiogenesis in PAH. Wnt7a expression correlates with tip formation via ROR2 (receptor tyrosine kinase-like orphan receptor 2), a tyrosine kinase receptor. We hypothesized that ROR2 activation in pulmonary microvascular endothelial cells (PMVECs) promotes angiogenesis, particularly endothelial barrier establishment, and its loss causes PAH.METHODS:Endothelial-specific ROR2 knockout (ROR2 ECKO) and wild-type mice were studied under normoxia and chronic hypoxia using echocardiography, hemodynamics, and lung morphometry. PMVECs from healthy and PAH lungs were transfected with ROR2 siRNA/constructs for functional and molecular studies. Focal adhesion activation and force generation were assessed via Förster resonance energy transfer-based methods. Bulk and si"}