# Verlies van ROR2-tyrosinekinase veroorzaakt endotheeldisfunctie bij PAH

*geplaatst 2026-02-04 · Hypertensie · Hypertension · doi https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.25881 · https://hartvaat.nl/2026/02/04/verlies-van-ror2-tyrosinekinase-veroorzaakt-endotheeldisfunctie-bij-pah/*

Endotheeldisfunctie is een kernkenmerk van pulmonale arteriële hypertensie. Eerdere studies toonden verlaagde Wnt7a-expressie. Dit onderzoek onthult dat verlies van de ROR2-tyrosinekinasereceptor leidt tot ongepaste integrine-β1-activatie en endotheeldisfunctie bij PAH.

## English: Loss of ROR2 Tyrosine Kinase Receptor Is Associated With Endothelial Dysfunction in PAH via Inappropriate Integrin β1 Activation

This study reveals that loss of the ROR2 tyrosine kinase receptor causes endothelial dysfunction in pulmonary arterial hypertension through inappropriate integrin beta1 activation, identifying a novel Wnt signalling pathway in PAH pathogenesis.

## Abstract (original, from the publication)

Hypertension, Volume 83, Issue 4, Page e25881, April 1, 2026. BACKGROUND:Endothelial dysfunction is a key feature of pulmonary arterial hypertension (PAH). Previously, we demonstrated decreased Wnt7a transcript levels, causing reduced angiogenesis in PAH. Wnt7a expression correlates with tip formation via ROR2 (receptor tyrosine kinase-like orphan receptor 2), a tyrosine kinase receptor. We hypothesized that ROR2 activation in pulmonary microvascular endothelial cells (PMVECs) promotes angiogenesis, particularly endothelial barrier establishment, and its loss causes PAH.METHODS:Endothelial-specific ROR2 knockout (ROR2 ECKO) and wild-type mice were studied under normoxia and chronic hypoxia using echocardiography, hemodynamics, and lung morphometry. PMVECs from healthy and PAH lungs were transfected with ROR2 siRNA/constructs for functional and molecular studies. Focal adhesion activation and force generation were assessed via Förster resonance energy transfer-based methods. Bulk and si

Auteurs: Ankita Mitra

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Bron: Hypertension, https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.25881. Bijgewerkt 2026-07-03T13:24:51Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.