# Concordante en discordante transcriptomische kenmerken van tweelingplacenta's bij pre-eclampsie

*geplaatst 2026-02-05 · Hypertensie · Hypertension · doi https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.25854 · https://hartvaat.nl/2026/02/05/concordante-en-discordante-transcriptomische-kenmerken-van-tweelingplacenta-s-bi/*

Meerlingzwangerschappen hebben een verhoogd pre-eclampsierisico, maar de onderliggende pathogenese kan verschillen van eenlingen. Deze studie onderzocht of tweelingplacenta's synchrone moleculaire kenmerken van pre-eclampsie tonen.

## English: Concordant and Discordant Transcriptomic Signatures of Twin Placentas in the Setting of Preeclampsia

RNA sequencing of individual twin placentas revealed both concordant and discordant transcriptomic signatures in preeclampsia, suggesting that the molecular pathogenesis may differ between monochorionic and dichorionic twin gestations.

## Abstract (original, from the publication)

Hypertension, Volume 83, Issue 6, Page e25854, June 1, 2026. BACKGROUND:Multifetal pregnancies have increased preeclampsia risk, but the underlying pathogenesis may differ from that of singletons. It remains unclear whether twin placentas show molecular signs of preeclampsia synchronously.METHODS:We performed RNA sequencing on 32 individual placental samples from twin gestations grouped by preeclampsia status: 24 dichorionic twin (DT) and 8 monochorionic twin gestations. Ten singleton placentas from preeclamptic pregnancies were also analyzed. A benchmark data set (GSE203507, GSE114691, and GSE1482410) and a test data set (GSE190973) comprised 71 early onset preeclampsia and 69 control singleton placentas. Differential abundance analysis was conducted, and machine learning was used to derive a novel 98-transcript classification signature (accuracy >0.97 in benchmark and test data sets).RESULTS:Across 7 groups, 2946 transcripts were differentially modulated (likelihood-ratio test; false discovery rate <0.05). Placental signature scoring distinguished normotensive from early onset preeclampsia in GSE203507 singletons (P<0.0001) although normotensive DTs did not differ from DTs with preeclampsia (Kruskal-Wallis/Dunn). Notably, some twin placentas without clinical preeclampsia exhibited preeclampsia-like profiles. Linear mixed-effects regression, which accounted for intertwin correlation structure, revealed increasing signature scores across singleton and DT groups (allP<0.01): normotensive singletons<normotensive DT<DT with preeclampsia<singletons with preeclampsia. Functional analysis in twins showed preeclampsia-like dysregulation but with pronounced variability. Intertwin divergence was more prominent in DT than in monochorionic twin samples, regardless of clinical diagnosis.CONCLUSIONS:These findings highlight the complexity of preeclampsia pathology in twins. In DT pregnancies complicated by preeclampsia, placental involvement may be asymmetrical, suggesting that disease may arise from a single affected placenta; however, these results require replication.

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Bron: Hypertension, https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.25854. Bijgewerkt 2026-07-03T13:24:50Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.