# Tenecteplase bij basilarisocclusie tot 24 uur: veelbelovende Lancet-data

*geplaatst 2026-02-05 · Cholesterol · The Lancet · doi https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00139-X/fulltext · https://hartvaat.nl/2026/02/05/tenecteplase-bij-basilarisocclusie-tot-24-uur-veelbelovende-lancet-data/*

Basilarisocclusie is de ernstigste presentatie van ischemisch CVA door groot-vaatocclusie. Nieuwe gerandomiseerde en observationele data in The Lancet ondersteunen de superioriteit van tenecteplase boven alteplase bij deze patiënten, ook buiten het conventionele tijdvenster van 4,5 uur.

## English: Intravenous tenecteplase for acute ischaemic stroke within 24 h due to basilar artery occlusion

This Lancet publication addresses basilar artery occlusion, the most severe presentation of large-vessel ischemic stroke, with new randomized and observational evidence supporting intravenous tenecteplase therapy within an extended 24-hour treatment window.

## Abstract (original, from the publication)

Basilar artery occlusion is a devastating condition with dismal prognosis and constitutes the most severe presentation of acute ischaemic stroke due to large-vessel occlusion.1 Randomised evidence on the safety and efficacy of intravenous thrombolysis in this stroke subtype is scarce, especially outside the conventional 0–4·5 h window.1,2 Tenecteplase is a third-generation tissue plasminogen activator with higher fibrin specificity and longer half-life than alteplase.3 Accruing randomised and observational evidence supports the superiority of tenecteplase over alteplase in patients who have had an acute ischaemic stroke, particularly those with large-vessel occlusion, in improving 3-month functional outcome assessed by the modified Rankin scale (mRS) score.

Auteurs: Georgios Tsivgoulis, Lina Palaiodimou, Guillaume Turc

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Bron: The Lancet, https://doi.org/https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00139-X/fulltext. Bijgewerkt 2026-07-03T13:24:33Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.