# ALDH2 rs671-variant versterkt plaatjesactivatie en arteriële trombose

*geplaatst 2026-02-06 · Algemeen · Circulation · doi https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.125.074318 · https://hartvaat.nl/2026/02/06/aldh2-rs671-variant-versterkt-plaatjesactivatie-en-arteriele-trombose/*

Een polymorfisme in aldehydedehydrogenase 2 (rs671) komt voor bij 30-50% van de Oost-Aziaten en is een risicofactor voor acuut myocardinfarct. Dit onderzoek toont dat deze variant de plaatjesactivatie en arteriële trombose versterkt.

## English: The Aldehyde Dehydrogenase 2 rs671 Variant Enhances Platelet Activation and Arterial Thrombosis

This study showed that the ALDH2 rs671 variant, present in 30-50% of East Asians, enhances platelet activation and arterial thrombosis, explaining the increased MI risk in carriers of this common genetic polymorphism.

## Abstract (original, from the publication)

BACKGROUND:Acute myocardial infarction (AMI) caused by thrombosis is a major cause of mortality. A polymorphism inAldh2gene (rs671) is found in approximately 30% to 50% of East Asians, and it is a risk factor for AMI. This mutation impairs aldehyde dehydrogenase 2 (ALDH2) function, but the effect of ALDH2 on platelet activation and thrombosis is unknown.METHODS:Platelets were isolated from platelet-specificAldh2knockout (Aldh2-/-) and ALDH2E506Kknock-in mice (which corresponds to humanAldh2rs671 gene mutation), as well as from healthy human donors with theAldh2rs671. Arterial thrombosis was measured in a FeCl3-induced thrombosis mouse model. The efficacy of Alda-1, an ALDH2 activator, in mitigating thrombogenesis was measured in ALDH2E506Kmice. Using a murine model of myocardial infarction (MI) model, we analyzed the effects of plateletAldh2on micro-thrombosis and infarct expansion post-MI. In addition, we enrolled 118 patients of differentAldh2rs671 genotypes (GG, GA, and AA) diagnose

Auteurs: Song Sun

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Bron: Circulation, https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.125.074318. Bijgewerkt 2026-07-03T13:24:49Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.