{"id":"77bce0554d8a","type":"article","url":"https://hartvaat.nl/2026/02/06/insulineresistentie-compromitteert-pentosefosfaatroute-en-lvad-gemedieerd-herste/","title":"Insulineresistentie compromitteert pentosefosfaatroute en LVAD-gemedieerd herstel bij obese hartfalenpatiënten","title_en":"Insulin Resistance Compromises the Pentose Phosphate Pathway and Impairs Left Ventricular Assist Device–Mediated Myocardial Recovery in Obese Patients with Heart Failure","category":"algemeen","category_label":"Algemeen","professions":["cardioloog"],"tags":["acuut-hartfalen","bisoprolol","carvedilol","empagliflozine","hfmref","hfpef","hfref","ijzersuppletie","ijzertekort","ivabradine","vrouwen"],"journal":"Circulation","doi":"https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.124.072850","source_url":"https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.124.072850","authors":["Tuo Pan"],"significance":6,"published":"2026-02-06","source_date":"2026-02-06","image":"","kennis":[],"congress":"","summary_en":"This study demonstrated that insulin resistance compromises the pentose phosphate pathway and impairs LVAD-mediated cardiac recovery, explaining why diabetic patients have worse myocardial recovery during mechanical support.","created":"2026-07-03T10:25:24Z","updated":"2026-07-03T18:38:15Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Eindstadium hartfalen is een mondiale gezondheidsuitdaging. LVAD's verbeteren de hartfunctie via mechanische ontlasting. Dit onderzoek toont dat insulineresistentie de pentosefosfaatroute compromitteert en daarmee het LVAD-gemedieerde myocardherstel bij obese patiënten belemmert.","abstract_original":"BACKGROUND:End-stage heart failure (HF) remains a major global health challenge, and left ventricular assist devices (LVADs) represent an important therapeutic option. LVAD-mediated mechanical unloading improves cardiac function and promotes myocardial recovery in many patients with HF; however, this recovery response is suboptimal in obese patients. The mechanisms by which LVAD-mediated unloading induces myocardial recovery, and how obesity alters these processes to blunt myocardial recovery, remain poorly understood.METHODS:Patients with HF receiving LVAD support were recruited to investigate the correlation between patients' body mass index and the myocardial recovery response following LVAD implantation. In parallel, a mouse model of heterotopic cervical heart transplantation was used to simulate LVAD-mediated cardiac unloading. Single-nucleus RNA sequencing and stable-isotope tracing metabolomics were performed to explore the changes of signaling pathways and metabolic processes i"}