# Insulineresistentie compromitteert pentosefosfaatroute en LVAD-gemedieerd herstel bij obese hartfalenpatiënten

*geplaatst 2026-02-06 · Algemeen · Circulation · doi https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.124.072850 · https://hartvaat.nl/2026/02/06/insulineresistentie-compromitteert-pentosefosfaatroute-en-lvad-gemedieerd-herste/*

Eindstadium hartfalen is een mondiale gezondheidsuitdaging. LVAD's verbeteren de hartfunctie via mechanische ontlasting. Dit onderzoek toont dat insulineresistentie de pentosefosfaatroute compromitteert en daarmee het LVAD-gemedieerde myocardherstel bij obese patiënten belemmert.

## English: Insulin Resistance Compromises the Pentose Phosphate Pathway and Impairs Left Ventricular Assist Device–Mediated Myocardial Recovery in Obese Patients with Heart Failure

This study demonstrated that insulin resistance compromises the pentose phosphate pathway and impairs LVAD-mediated cardiac recovery, explaining why diabetic patients have worse myocardial recovery during mechanical support.

## Abstract (original, from the publication)

BACKGROUND:End-stage heart failure (HF) remains a major global health challenge, and left ventricular assist devices (LVADs) represent an important therapeutic option. LVAD-mediated mechanical unloading improves cardiac function and promotes myocardial recovery in many patients with HF; however, this recovery response is suboptimal in obese patients. The mechanisms by which LVAD-mediated unloading induces myocardial recovery, and how obesity alters these processes to blunt myocardial recovery, remain poorly understood.METHODS:Patients with HF receiving LVAD support were recruited to investigate the correlation between patients' body mass index and the myocardial recovery response following LVAD implantation. In parallel, a mouse model of heterotopic cervical heart transplantation was used to simulate LVAD-mediated cardiac unloading. Single-nucleus RNA sequencing and stable-isotope tracing metabolomics were performed to explore the changes of signaling pathways and metabolic processes i

Auteurs: Tuo Pan

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Bron: Circulation, https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.124.072850. Bijgewerkt 2026-07-03T18:38:15Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.