{"id":"ac10c293570c","type":"article","url":"https://hartvaat.nl/2026/02/06/natuurlijk-beloop-van-histologisch-bewezen-acute-eosinofiele-myocarditis/","title":"Natuurlijk beloop van histologisch bewezen acute eosinofiele myocarditis","title_en":"Natural History of Patients With Histologically Proven Acute Eosinophilic Myocarditis","category":"algemeen","category_label":"Algemeen","professions":["cardioloog"],"tags":["acuut-hartfalen","aficamten"],"journal":"Circulation","doi":"https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.125.074797","source_url":"https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.125.074797","authors":["Enrico Ammirati"],"significance":7,"published":"2026-02-06","source_date":"2026-02-06","image":"","kennis":["https://hartvaat.nl/kennis/farmacologie/betablokkers-cardiale-indicaties/"],"congress":"","summary_en":"This Circulation study characterized the natural history of histologically proven acute eosinophilic myocarditis, providing the first large registry data on clinical presentation, treatment, and outcomes of this rare but severe form of myocardial inflammation.","created":"2026-07-03T10:25:24Z","updated":"2026-07-03T13:24:49Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Er bestaan geen grote registers van acute eosinofiele myocarditis (EM). EM wordt gezien als een cardiale aandoening met hoge mortaliteit bij voornamelijk jonge en middelbare volwassenen. Dit onderzoek beschrijft het natuurlijk beloop op basis van histologisch bewezen gevallen.","abstract_original":"BACKGROUND:No large registries of patients with acute eosinophilic myocarditis (EM) are available. However, EM is perceived as a cardiac disease with high mortality, affecting mainly young and middle-aged adults according to small series and case reports. Awareness of the clinical presentation, associated systemic conditions, treatments, and outcomes of this uncommon condition is an unmet need.METHODS:In this international, multicenter, retrospective cohort study, 53 centers screened 193 patients with histologically proven acute EM between 1992 and 2023. After the exclusion of patients with insufficient data (n=10), symptoms lasting >30 days (n=19), or histological diagnosis not confirmed after review (n=8), 156 patients were included.RESULTS:Median age at presentation was 48 years (first to third quartile, 34–59 years) with male predominance (67.3%), and only 2 were pediatric cases (≤16 years of age; 1.3%). The main signs and symptoms at presentation were dyspnea (75.6%), fever"}