{"id":"0d05850aeb90","type":"article","url":"https://hartvaat.nl/2026/02/09/podocyt-endotheline-1-en-endotheelcel-eta-receptoren-essentieel-bij-fsgs/","title":"Podocyt-endotheline-1 en endotheelcel-ETA-receptoren essentieel bij FSGS","title_en":"Podocyte-derived endothelin-1 and endothelial cell endothelin A receptors are essential for glomerular injury in mouse models of focal segmental glomerulosclerosis","category":"chronische nierziekte","category_label":"Nierziekte","professions":["internist"],"tags":["aprocitentan","endotheel","endothelineantagonisten"],"journal":"Kidney International","doi":"https://www.kidney-international.org/article/S0085-2538(26)00077-3/fulltext","source_url":"https://doi.org/https://www.kidney-international.org/article/S0085-2538(26)00077-3/fulltext","authors":["Liping Yu","Ubong S. Ekperikpe","Hunter W. Korsmo","Serena Zhao","Zhengzi Yi","Jonathan Haydak","Sean Lefferts","Kristin Meliambro","Kirk N. Campbell","Evren U. Azeloglu","Donald E. Kohan","Phillip J. McCown","Abhijit S. Naik","Edgar A. Otto","Börje Haraldsson","Weijia Zhang","Ilse S. Daehn"],"significance":4,"published":"2026-02-09","source_date":"2026-02-09","image":"","kennis":[],"congress":"","summary_en":"This study demonstrates that podocyte-derived endothelin-1 and glomerular endothelial cell endothelin A receptors are essential for glomerular injury in mouse models of focal segmental glomerulosclerosis, establishing a podocyte-endothelial crosstalk mechanism.","created":"2026-07-03T10:25:24Z","updated":"2026-07-03T13:24:49Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Verhoogde endotheline-1- en ETA-signalering zijn betrokken bij focale segmentale glomerulosclerose. Dit onderzoek toont dat podocyt-afkomstig endotheline-1 en endotheelcel-ETA-receptoren essentieel zijn voor glomerulaire schade in muismodellen van FSGS.","abstract_original":"Increased endothelin-1 (ET1) and endothelin receptor A (ETA) signaling have been implicated in the pathogenesis of focal segmental glomerulosclerosis (FSGS). Previous studies have suggested that crosstalk between activated podocytes and glomerular endothelial cells (GECs) could contribute to the pathogenesis of FSGS."}