# Gepersonaliseerde leefstijlinterventie verbetert AF-ablatie-uitkomsten

*geplaatst 2026-02-11 · Atriumfibrilleren · European heart journal · doi 10.1093/eurheartj/ehaf689 · https://hartvaat.nl/2026/02/11/gepersonaliseerde-leefstijlinterventie-verbetert-af-ablatie-uitkomsten/*

Studie bevestigde dat geïntegreerde leefstijlinterventie (gewicht, fitness, slaap, alcohol) de AF-ablatie-uitkomsten significant verbetert. Leefstijl is een essentieel onderdeel van AF-management.

## English: Improving outcomes of atrial fibrillation ablation by integrated personalized lifestyle interventions: a randomized controlled trial.

This randomized trial confirmed that integrated personalized lifestyle interventions (weight management, fitness, sleep optimization, alcohol reduction) significantly improve catheter ablation outcomes for atrial fibrillation.

## Abstract (original, from the publication)

BACKGROUND AND AIMS: Atrial fibrillation (AF) is associated with various lifestyle risk factors. Their presence negatively affects AF catheter ablation outcomes. This study evaluates the efficacy of a nurse-led, integrated lifestyle programme on ablation outcomes. METHODS: POP-AF is a prospective, randomized, controlled trial involving patients referred for their first AF ablation. Patients were assigned in a 1:1 ratio to standard pre-ablation counselling by the treating electrophysiologist, or a nurse-led integrated lifestyle clinic, including a home sleep apnoea test, weight reduction, alcohol reduction, smoking cessation, and optimal hypertension and hypercholesterolaemia treatment before undergoing pulmonary vein isolation (PVI). The primary endpoint was a composite of hospitalizations for repeat ablations and direct current cardioversions in an event-rate analysis up to 12 months after pulsed-field pulmonary vein isolation. RESULTS: A total of 145 patients participated in the trial; 70 patients were assigned to the control group, and 75 patients were assigned to the integrated lifestyle treatment (ILT) group. The median age of patients was 62 years, 26% were women, and 59% had persistent AF. Median ILT duration was 5 months. The primary endpoint occurred 52 times (492/1000 patient-years) in the control group and 25 times (240/1000 patient-years) in the ILT group [incidence relative risk (RR) 0.49, 95% confidence interval (CI) 0.30-0.78, P = .004]. The rates of repeat ablations (RR 0.43, 95% CI 0.18-0.94, P = .045) and direct current cardioversions (RR 0.52, 95% CI 0.28-0.92, P = .031) were also lower in the ILT group. CONCLUSIONS: Integrated lifestyle modification before catheter ablation reduces both repeat ablations and direct current cardioversions by half until 12 months after index ablation.

Auteurs: Jasper Vermeer, Tineke Vinck-de Greef, Maarten van den Broek, Bianca de Louw, Gijs van Steenbergen, Dennis van Veghel, Lukas Dekker

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Bron: European heart journal, https://doi.org/10.1093/eurheartj/ehaf689. Bijgewerkt 2026-07-03T13:31:09Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.