{"id":"5c2013875f4e","type":"article","url":"https://hartvaat.nl/2026/02/12/multi-lijns-assemblage-brengt-ruimtelijke-orde-in-menselijke-nierorganoiden/","title":"Multi-lijns assemblage brengt ruimtelijke orde in menselijke nierorganoïden","title_en":"Multilineage assembly brings spatial order to human kidney organoids","category":"chronische nierziekte","category_label":"Nierziekte","professions":["internist"],"tags":[],"journal":"Kidney International","doi":"https://www.kidney-international.org/article/S0085-2538(25)01013-0/fulltext","source_url":"https://doi.org/https://www.kidney-international.org/article/S0085-2538(25)01013-0/fulltext","authors":["Chao Zhang","Meng Liu","Yun Xia"],"significance":4,"published":"2026-02-12","source_date":"2026-02-12","image":"","kennis":[],"congress":"","summary_en":"This review discusses how multilineage assembly approaches bring spatial organisation to human kidney organoids, representing a critical advance toward generating functional kidney models with physiological architecture.","created":"2026-07-03T10:25:22Z","updated":"2026-07-03T13:24:48Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Een volwassen nier bevat meer dan 30 celtypen en circa 1 miljoen nefronen. Dit overzicht bespreekt hoe multi-lijns assemblage ruimtelijke organisatie aanbrengt in nierorganoïden, een belangrijke stap naar functionele niermodellen.","abstract_original":"An adult human kidney is composed of >30 different types of cells. Its full functionality depends not only on the diversity of these cells, but also on their precise spatial organization. On average, each human kidney contains approximately 1 million nephrons, all of which drain into a single ureteral outlet. This remarkable spatial architecture is orchestrated by reciprocal interaction between 2 key progenitor populations: nephron progenitor cell (NPC) and ureteric progenitor cell (UPC). During kidney morphogenesis, these progenitors interact in a highly concerted manner, ensuring that multiple nephrons connect seamlessly to a single collecting duct (CD) tree."}