{"id":"67f0af90e1a0","type":"article","url":"https://hartvaat.nl/2026/02/13/ccr8-expressie-op-regulatoire-t-cellen-beschermt-tegen-myocardinfarctschade/","title":"CCR8-expressie op regulatoire T-cellen beschermt tegen myocardinfarctschade","title_en":"CCR8 Expression on Regulatory T Cells Reveals Trajectories of Tissue Adaptation and Protects Against Myocardial Infarction–Induced Tissue Damage","category":"algemeen","category_label":"Algemeen","professions":["cardioloog"],"tags":["laminopathie"],"journal":"Circulation","doi":"https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.125.076426","source_url":"https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.125.076426","authors":["Nana Li"],"significance":6,"published":"2026-02-13","source_date":"2026-02-13","image":"","kennis":[],"congress":"","summary_en":"This study mapped the developmental trajectory of regulatory T cells after MI using single-cell RNA sequencing, showing that CCR8-positive Tregs accumulate in the heart and play a vital role in limiting post-infarction inflammation.","created":"2026-07-03T10:25:07Z","updated":"2026-07-03T13:24:34Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Via single-cell RNA-sequencing werd het ontwikkelingstraject van regulatoire T-cellen na myocardinfarct in kaart gebracht. CCR8-positieve T-regs bleken essentieel voor weefseladaptatie en bescherming tegen infarctschade, wat nieuwe therapeutische mogelijkheden opent voor immuunmodulatie na een hartinfarct.","abstract_original":"BACKGROUND:Tissue-specific regulatory T cells (Tregs) accumulate in the heart after myocardial infarction (MI) and play a vital role in limiting inflammation and promoting tissue repair. However, the developmental trajectory of heart Tregs and the molecular cues that guide their recruitment to the heart remain poorly understood, impeding therapeutic strategies that leverage Treg-mediated cardiac protection.METHODS:We used single-cell and bulk RNA sequencing in a murine MI model to delineate the differentiation trajectory of Tregs from mediastinal lymph nodes to the heart. Functional validation was performed using Treg-specificCcr8(CC motif chemokine receptor 8) knockout mice (Ccr8flox/floxFoxp3Cre),Ccl1(CC motif chemokine ligand 1) knockout mice (Ccl1−/−), macrophage-targetedCcl1knockdown mice,Ccl1-overexpressing mice, and DEREG mice. The CCL1-CCR8 axis was evaluated in cardiac tissues and circulating blood from patients with MI.RESULTS:Single-cell RNA sequencing revealed a stepwise di"}