{"id":"2746ea559c7e","type":"article","url":"https://hartvaat.nl/2026/02/13/endotheliale-prolylhydroxylase-3-vermindert-maladaptieve-inflammatie-bij-nierher/","title":"Endotheliale prolylhydroxylase 3 vermindert maladaptieve inflammatie bij nierherstel na ischemie","title_en":"Endothelial prolyl hydroxylase 3 mitigates maladaptive inflammation to promote post-ischemic kidney repair","category":"chronische nierziekte","category_label":"Nierziekte","professions":["internist"],"tags":[],"journal":"Kidney International","doi":"https://www.kidney-international.org/article/S0085-2538(26)00089-X/fulltext","source_url":"https://doi.org/https://www.kidney-international.org/article/S0085-2538(26)00089-X/fulltext","authors":["Rajni Sharma","Ratnakar Tiwari","Yalu Zhou","James O'Sullivan","Hiroshi Maekawa","Gabriella S. Borkowski","Haris Bukaric","Si Young An","Edward B. Thorp","Navdeep S. Chandel","Susan E. Quaggin","Pinelopi P. Kapitsinou"],"significance":4,"published":"2026-02-13","source_date":"2026-02-13","image":"","kennis":["https://hartvaat.nl/kennis/nierziekte/nierziekte-en-cardiovasculair-risico/","https://hartvaat.nl/kennis/nierziekte/nsaids-en-nierziekte/"],"congress":"","summary_en":"This study demonstrates that endothelial prolyl hydroxylase 3 mitigates maladaptive inflammation to promote post-ischaemic kidney repair, linking dysregulated oxygen sensing in endothelial cells to CKD progression after acute kidney injury.","created":"2026-07-03T10:25:21Z","updated":"2026-07-03T13:24:47Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Acuut nierletsel is een risicofactor voor CKD-ontwikkeling. Weefselhypoxie beïnvloedt het biologisch gedrag van parenchymale en immuuncellen. Dit onderzoek toont dat endotheliale prolylhydroxylase 3 maladaptieve inflammatie remt en post-ischemisch nierherstel bevordert.","abstract_original":"Acute kidney injury (AKI) is a major health concern and well-established risk factor for the development of chronic kidney disease (CKD). Tissue hypoxia is a prominent feature of the injured kidney that shapes the biological behavior of parenchymal and immune cells. Endothelial cells have important immunomodulatory roles, but the impact of dysregulated oxygen sensing on their responses remains poorly understood."}