{"id":"781862e27a4c","type":"article","url":"https://hartvaat.nl/2026/02/13/genetisch-bepaalde-afkomst-en-morfologische-en-moleculaire-kenmerken-van-carotis/","title":"Genetisch bepaalde afkomst en morfologische en moleculaire kenmerken van carotisplaques","title_en":"Genetically determined ancestry associates with morphological and molecular carotid plaque features","category":"cholesterol","category_label":"Cholesterol","professions":["cardioloog","internist"],"tags":[],"journal":"Atherosclerosis","doi":"https://www.atherosclerosis-journal.com/article/S0021-9150(26)00046-8/fulltext","source_url":"https://doi.org/https://www.atherosclerosis-journal.com/article/S0021-9150(26)00046-8/fulltext","authors":["Nima Fahim","Tim R. Sakkers","Floor B.H. van der Zalm","Joost Hoekstra","Dominique P.V. de Kleijn","Michal Mokry","Jose Verdezoto Mosquera","Gerard Pasterkamp","Hester M. den Ruijter","Clint L. Miller","Jessica van Setten","Sander W. van der Laan"],"significance":5,"published":"2026-02-13","source_date":"2026-02-13","image":"","kennis":["https://hartvaat.nl/kennis/preventie/risicofactoren-cardiovasculair/"],"congress":"","summary_en":"This study examined how genetically determined ancestry associates with morphological and molecular features of carotid atherosclerotic plaques. Genome-informed ancestry offers a more accurate framework for studying ethnic disparities in cardiovascular disease burden.","created":"2026-07-03T10:25:21Z","updated":"2026-07-03T13:24:47Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Atherosclerose wordt beïnvloed door leeftijd, geslacht, diabetes en andere factoren die variëren tussen etnische groepen. Deze studie onderzocht hoe genetisch bepaalde afkomst samenhangt met morfologische en moleculaire kenmerken van carotisplaques.","abstract_original":"Cardiovascular disease (CVD) is the primary global cause of death, accounting for nearly 17.9 million deaths annually, with over 75% occurring in low- and middle-income countries [1]. Atherosclerosis, its main driver, is influenced by gender, aging, smoking, hypertension, family history and genetics, type 2 diabetes, lifestyle, and dyslipidemia – risk factors that correlate with socio-economic status and may vary across ethnicities [2–4]. However, they fail to fully explain observed ethnic disparities in relative rates of CVD [3,4]."}