{"id":"52b9ef150cf9","type":"article","url":"https://hartvaat.nl/2026/02/13/verhoogde-wiggendruk-bij-groep-1-pulmonale-hypertensie/","title":"Verhoogde wiggendruk bij groep 1 pulmonale hypertensie","title_en":"Elevated Pulmonary Artery Wedge Pressure in Group 1 Pulmonary Hypertension","category":"algemeen","category_label":"Algemeen","professions":["cardioloog"],"tags":["anemie-ckd","bloeddrukbehandeling","pulmonale-hypertensie","renale-denervatie"],"journal":"Circulation","doi":"https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.125.077606","source_url":"https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.125.077606","authors":[],"significance":7,"published":"2026-02-13","source_date":"2026-02-13","image":"","kennis":["https://hartvaat.nl/kennis/antistolling/antistolling-bij-kankerpatienten/","https://hartvaat.nl/kennis/vasculair/chronisch-trombo-embolische-ph/"],"congress":"","summary_en":"This Circulation study examined elevated pulmonary artery wedge pressure in patients with group 1 pulmonary hypertension, exploring the clinical significance and management implications of this hemodynamic overlap between pre- and post-capillary disease.","created":"2026-07-03T10:25:22Z","updated":"2026-07-03T18:38:15Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Bij pulmonale hypertensie wordt een PAWP >15 mmHg gebruikt om linkerhartdisfunctie te diagnosticeren, maar sommige patiënten met bevestigde groep 1 PH tonen toch een verhoogde wiggendruk. Deze studie onderzocht de kenmerken en implicaties van dit fenomeen.","abstract_original":"BACKGROUND:With pulmonary hypertension (PH), a pulmonary artery wedge pressure (PAWP)>15 mm Hg is used to diagnose left heart dysfunction, but some patients with adjudicated group 1 PH demonstrate PAWP>15 mm Hg. The primary objective of the study was to evaluate group 1 PH with high PAWP>15 mm Hg.METHODS:Patients with adjudicated group 1 PH from PVDOMICS between 2016 and 2019 were separated into high PAWP(>15 mm Hg) or normal PAWP and compared with adjudicated combined pre- and postcapillary (Cpc) PH related to heart failure with preserved ejection fraction (HFpEF). Participants underwent dynamic right heart catheterization and metabolomics. Findings were validated in 3 independent cohorts with adjudicated group 1 PH (validation cohorts 1 and 2 with exercise right heart catheterization and validation cohort 3 with resting right heart catheterization).RESULTS:Of 325 patients with group 1 PH (73% women, mean age 53.0±14.3 years), 15% (n=48) had high PAWP. Grou"}