{"id":"c4361b7e8257","type":"article","url":"https://hartvaat.nl/2026/02/16/fibrilline-1-is-een-nieuw-ligand-van-de-egf-receptor-dat-mesangiumcellen-activee/","title":"Fibrilline-1 is een nieuw ligand van de EGF-receptor dat mesangiumcellen activeert","title_en":"Fibrillin-1 is a novel ligand of the epidermal growth factor receptor promoting mesangial cell activation and glomerulosclerosis","category":"chronische nierziekte","category_label":"Nierziekte","professions":["internist"],"tags":[],"journal":"Kidney International","doi":"https://www.kidney-international.org/article/S0085-2538(26)00090-6/fulltext","source_url":"https://doi.org/https://www.kidney-international.org/article/S0085-2538(26)00090-6/fulltext","authors":["Meizhi He","Liuyan Xiao","Zhao Liu","Wenjian Min","Jiongcheng Chen","Xue Hong","Peng Yang","Haiyan Fu","Li Li","Youhua Liu"],"significance":4,"published":"2026-02-16","source_date":"2026-02-16","image":"","kennis":[],"congress":"","summary_en":"This study reveals that fibrillin-1 is a novel ligand of the epidermal growth factor receptor that promotes mesangial cell activation and glomerulosclerosis, identifying a new mechanism connecting podocyte damage to mesangial pathology.","created":"2026-07-03T10:25:21Z","updated":"2026-07-03T13:24:46Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Podocytenschade en mesangiumactivatie zijn kenmerken van glomerulaire ziekten. Dit onderzoek onthult dat fibrilline-1 een nieuw ligand is van de epidermale groeifactorreceptor dat mesangiumcelactivatie en glomerulosclerose bevordert.","abstract_original":"Podocyte injury and mesangial activation are hallmarks of a wide variety of glomerular diseases. Although podocyte damage is thought to be an early event that causes subsequent mesangial activation, the mechanism connecting these two events remains poorly understood. Since the protein fibrillin-1 (FBN1) may be involved in glomerular injury in several kidney diseases, we tested whether FBN1 expression in injured podocytes trigger mesangial cell activation and proliferation."}