# Telomeerherstel via gentherapie bij cardiorenaal syndroom type 4

*geplaatst 2026-02-18 · Nierziekte · Kidney International · doi https://www.kidney-international.org/article/S0085-2538(26)00130-4/fulltext · https://hartvaat.nl/2026/02/18/telomeerherstel-via-gentherapie-bij-cardiorenaal-syndroom-type-4/*

Cardiorenaal syndroom type 4 is hartfalen veroorzaakt door chronische nierziekte. Cardiovasculaire mortaliteit is de belangrijkste doodsoorzaak bij gevorderd CKD. Dit onderzoek onderzocht telomeerherstel via gentherapie als potentiële strategie.

## English: Telomere recapping via gene therapy as a beneficial strategy for cardio-renal syndrome type 4

This study investigated telomere recapping via gene therapy as a beneficial strategy for cardiorenal syndrome type 4, where heart failure is driven by chronic kidney disease. The approach addresses the shortened telomere lengths observed in advanced CKD patients.

## Abstract (original, from the publication)

Cardio-renal syndrome type 4 (CRS4) is defined as heart failure driven by chronic kidney disease (CKD). Cardiovascular mortality is the leading cause of death in patients with advanced CKD with current medical treatments exhibiting limited efficacy. Short leukocyte telomere lengths in such patients are correlated with increased mortality, particularly cardiovascular mortality. Here, we examined telomere shortening in mouse and human cardiomyocyte models of CRS4 and its potential protective role by overexpression of telomerase reverse transcriptase.

Auteurs: Danshu Xie, Chenguang Wang, Xin Wan, Longyu Wang, Yinlong Zhao, Jianan Pan, Yushu Zhao, Jiaying Ji, Jiaolun Li, Yangyang Liu, Feng Ding, Alex C.Y. Chang, Wei Ding

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Bron: Kidney International, https://doi.org/https://www.kidney-international.org/article/S0085-2538(26)00130-4/fulltext. Bijgewerkt 2026-07-03T13:24:45Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.