{"id":"cd1de7239f04","type":"article","url":"https://hartvaat.nl/2026/02/19/mettl3-interventie-onderdrukt-pathogene-th17-differentiatie-en-herstelt-nierscha/","title":"METTL3-interventie onderdrukt pathogene Th17-differentiatie en herstelt nierschade bij lupusnefritis","title_en":"METTL3-targeted intervention on nuclear factors RORA/RORγt suppressing pathogenic T helper 17 cell differentiation and restores kidney damage in lupus nephritis.","category":"chronische nierziekte","category_label":"Nierziekte","professions":["internist"],"tags":[],"journal":"Kidney International","doi":"https://www.kidney-international.org/article/S0085-2538(26)00133-X/fulltext","source_url":"https://doi.org/https://www.kidney-international.org/article/S0085-2538(26)00133-X/fulltext","authors":["Xinhang Xia","Chunhao Long","Wenwen Chen","Xuyang Yao","Binbing Xu","Huilin Teng","Yanli Fang","Qihui Xu","Cong Zhang","Mingli Chen","Zhangyi Xie","Xinya Tong","Aqiong Chen","Feifei Hu","Xiangyang Xue","Huidi Zhang","Gangqiang Guo"],"significance":4,"published":"2026-02-19","source_date":"2026-02-19","image":"","kennis":["https://hartvaat.nl/kennis/farmacologie/aldosteron-en-raas-farmacologie/"],"congress":"","summary_en":"This study reveals that METTL3-mediated m6A modification of nuclear factors RORA/RORgammat suppresses pathogenic Th17 cell differentiation and restores kidney damage in lupus nephritis, identifying a new epigenetic regulatory mechanism.","created":"2026-07-03T10:25:19Z","updated":"2026-07-03T13:24:45Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Abnormale Th17-celdifferentiatie speelt een belangrijke rol bij lupusnefritis. Dit onderzoek toont dat m6A-modificatie via METTL3 de nucleaire factoren RORA/RORγt reguleert, waardoor Th17-differentiatie onderdrukt wordt en nierschade vermindert.","abstract_original":"Abnormal differentiation of T helper 17 (Th17) cells is an important mechanism underlying lupus nephritis (LN) pathogenesis. However, its driving mechanism remains unclear. Modification of m6A, the most dominant RNA modification, is a novel mechanism for regulating cell phenotypes and functions, with methyltransferase-like 3 (METTL3) being an important methyltransferase. Nonetheless, whether m6A modification participates in the regulation of Th17 cell differentiation in patients with LN has not been reported."}