{"id":"7464f64565ba","type":"article","url":"https://hartvaat.nl/2026/02/19/partner-3-tavr-versus-chirurgie-bij-laagrisico-zevenjaarsresultaten-nejm/","title":"PARTNER 3: TAVR versus chirurgie bij laagrisico — zevenjaarsresultaten NEJM","title_en":"Transcatheter or Surgical Aortic-Valve Replacement in Low-Risk Patients at 7 Years.","category":"hartfalen","category_label":"Hartfalen","professions":["cardioloog"],"tags":[],"journal":"The New England journal of medicine","doi":"10.1056/NEJMoa2509766","source_url":"https://doi.org/10.1056/NEJMoa2509766","authors":["Martin B Leon","Michael J Mack","Philippe Pibarot","Rebecca T Hahn","Vinod H Thourani","S H Kodali","Philippe Généreux","Samir R Kapadia","David J Cohen","Stuart J Pocock","Yiran Zhang","Molly Szerlip","Julien Ternacle","S Chris Malaisrie","Howard C Herrmann","Wilson Y Szeto","Mark J Russo","Vasilis Babaliaros","Tamim Nazif","John G Webb","Raj R Makkar"],"significance":9,"published":"2026-02-19","source_date":"2026-02-19","image":"","kennis":[],"congress":"","summary_en":"The 7-year PARTNER 3 results confirmed comparable outcomes between TAVR and surgical aortic valve replacement in low-risk patients, with maintained valve durability and no excess structural deterioration. These are the longest-term data supporting TAVR across the full surgical risk spectrum.","created":"2026-07-03T10:32:12Z","updated":"2026-07-03T13:31:10Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Zevenjaarsresultaten van PARTNER 3 bevestigden vergelijkbare uitkomsten van TAVR en chirurgie bij laagrisicopatiënten. De langetermijnduurzaamheid van TAVR is geruststellend tot 7 jaar.","abstract_original":"BACKGROUND: Five-year data from the PARTNER 3 trial showed that among low-risk patients with severe, symptomatic aortic stenosis, outcomes were similar among patients who had undergone transcatheter aortic-valve replacement (TAVR) and those who had undergone surgical aortic-valve replacement. Longer-term assessments of clinical outcomes and valve durability are needed. METHODS: Patients were randomly assigned in a 1:1 ratio to undergo transfemoral TAVR or surgery. The first primary end point was a nonhierarchical composite of death, stroke, or rehospitalization related to the procedure, the valve, or heart failure. The second primary end point was a hierarchical composite of death, disabling stroke, nondisabling stroke, and the number of rehospitalization days related to the procedure, the valve, or heart failure, analyzed with the use of a win ratio analysis. Clinical, echocardiographic, valve-durability, and health-status end points were assessed through 7 years. RESULTS: A total of 1000 patients underwent randomization. In the analysis of the first primary end point, the Kaplan-Meier estimate of the incidence of an end-point event was 34.6% with TAVR and 37.2% with surgery (difference, -2.6 percentage points; 95% confidence interval [CI], -9.0 to 3.7). The win ratio for the second primary end point was 1.04 (95% CI, 0.84 to 1.30). In the TAVR and surgery groups, respectively, the Kaplan-Meier estimates for the incidence of components of the first primary end point were as follows: death, 19.5% and 16.8%; stroke, 8.5% and 8.1%; and rehospitalization, 20.6% and 23.5%. The mean (±SD) aortic-valve gradients assessed by echocardiography at 7 years were 13.1±8.5 mm Hg after TAVR and 12.1±6.3 mm Hg after surgery. The percentage of bioprosthetic valves that failed was 6.9% in the TAVR group and 7.5% in the surgery group. Patient-reported outcomes were similar in the two groups. CONCLUSIONS: Among low-risk patients with severe, symptomatic aortic stenosis, no significant differences with respect to two primary composite end points involving death, stroke, and rehospitalization were observed at 7 years between those who had undergone TAVR and those who had undergone surgery. (Funded by Edwards Lifesciences; PARTNER 3 ClinicalTrials.gov number, NCT02675114.)."}