{"id":"2201ddadf356","type":"article","url":"https://hartvaat.nl/2026/02/20/hev-gericht-antilichaam-medicijnconjugaat-bevordert-langdurige-acceptatie-van-ha/","title":"HEV-gericht antilichaam-medicijnconjugaat bevordert langdurige acceptatie van harttransplantaat","title_en":"HEV-Targeted Antibody-Drug Conjugate Promotes Long-Term Cardiac Allograft Acceptance","category":"algemeen","category_label":"Algemeen","professions":["cardioloog"],"tags":["harttransplantatie"],"journal":"Circulation","doi":"https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.125.076423","source_url":"https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.125.076423","authors":["Yanjia Che"],"significance":5,"published":"2026-02-20","source_date":"2026-02-20","image":"","kennis":[],"congress":"","summary_en":"This study developed an HEV-targeted antibody-drug conjugate that promotes long-term cardiac allograft acceptance by modulating naive T-cell trafficking through lymph node high endothelial venules. The approach represents a novel immunomodulatory strategy for transplantation.","created":"2026-07-03T10:25:19Z","updated":"2026-07-03T13:24:44Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"De toegang van naïeve T-cellen tot lymfeklieren via hoge endotheliale venulen (HEV's) is cruciaal voor transplantaatacceptatie. Deze studie onderzocht een HEV-gericht antilichaam-medicijnconjugaat als strategie om langdurige acceptatie van een hartallograft te bevorderen.","abstract_original":"BACKGROUND:The entrance of naive T cells into lymph nodes (LNs) is a crucial step for induction of heart transplant acceptance under costimulatory blockade. Specialized blood vessels within the LN known as high endothelial venules (HEVs) mediate this process. HEVs express a key glycoprotein containing 6-sulfo sialyl Lewis X, the binding site for L-selectin on the membrane of naive T cells. The proper formation of this carbohydrate requires sulfation by N-acetylglucosamine 6-O-sulfotransferases, particularly CHST4. Given the critical role of CHST4 in HEVs and transplant immunity, we aimed to develop a first-in-class antibody-drug conjugate (ADC) targeting the CHST4/HEV axis to deliver immunoregulatory molecules to LNs and promote long-term cardiac transplant survival.METHODS:We used CHST4 knockout mice and inducible diphtheria toxin receptor mouse models to investigate the role of CHST4 in HEV function during heart allograft transplantation. To assess the impact of CHST4 deficiency on h"}