{"id":"14dbec3c1982","type":"article","url":"https://hartvaat.nl/2026/02/20/milt-norepinefrine-2-adrenerge-as-verergert-sepsis-geassocieerd-acuut-nierletsel/","title":"Milt-norepinefrine-β2-adrenerge as verergert sepsis-geassocieerd acuut nierletsel","title_en":"The splenic norepinephrine–β2-adrenergic receptor axis aggravates sepsis-associated acute kidney injury via neutrophil-mediated immunosuppression","category":"chronische nierziekte","category_label":"Nierziekte","professions":["internist"],"tags":[],"journal":"Kidney International","doi":"https://www.kidney-international.org/article/S0085-2538(26)00132-8/fulltext","source_url":"https://doi.org/https://www.kidney-international.org/article/S0085-2538(26)00132-8/fulltext","authors":["Shuai Ma","Xiaoqian Hu","Bo Deng","Yaqi Wan","Wenchang Meng","Zhihao Wu","Juan Liu","Xuezhu Li","Lingyun Shao","Xuguang Yang","Feng Ding","Yuli Lin"],"significance":4,"published":"2026-02-20","source_date":"2026-02-20","image":"","kennis":[],"congress":"","summary_en":"This study uncovers a neural mechanism whereby the splenic norepinephrine-beta2-adrenergic receptor axis aggravates sepsis-associated acute kidney injury through neutrophil-mediated immunosuppression.","created":"2026-07-03T10:25:18Z","updated":"2026-07-03T13:24:44Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Sepsis-geassocieerd acuut nierletsel gaat vaak gepaard met immuunparalyse en nierinfectie. Dit onderzoek onthult een neuraal mechanisme waarbij de milt via norepinefrine en β2-adrenerge receptoren de immuunrespons onderdrukt via neutrofiel-gemedieerde immunosuppressie.","abstract_original":"Sepsis-associated acute kidney injury (SA-AKI) is frequently complicated by immune paralysis and kidney infection. Despite the spleen’s critical immunological role, the neural mechanisms regulating the splenic immune responses during SA-AKI remain unclear."}