{"id":"1c59170ca3e5","type":"article","url":"https://hartvaat.nl/2026/02/23/luchtvervuiling-en-multimorbiditeit-verhogen-het-risico-op-atriumfibrilleren/","title":"Luchtvervuiling en multimorbiditeit verhogen het risico op atriumfibrilleren","title_en":"Impact of air pollution and multimorbidity on the risk of incident atrial fibrillation","category":"atriumfibrilleren","category_label":"Atriumfibrilleren","professions":["cardioloog","huisarts"],"tags":["abelacimab","acuut-hartfalen","biomarkers-cardiovasculair","bloeddrukbehandeling","laminopathie","slaapapneu"],"journal":"Heart","doi":"http://heart.bmj.com/cgi/content/short/112/6/318?rss=1","source_url":"https://doi.org/http://heart.bmj.com/cgi/content/short/112/6/318?rss=1","authors":["Zhang","J.","Chen","G.","Wei","S.","Li","W.","Lip","G. Y. H.","Lin","H."],"significance":6,"published":"2026-02-23","source_date":"2026-02-23","image":"https://hartvaat.nl/global/img/e8315535d29a.webp","kennis":["https://hartvaat.nl/kennis/atriumfibrilleren/chadsvasc-score/"],"congress":"","summary_en":"This UK Biobank study of 480,000 participants showed that air pollution exposure interacts with multimorbidity to increase AF risk, demonstrating synergistic effects between environmental and clinical risk factors.","created":"2026-07-03T10:25:07Z","updated":"2026-07-03T18:38:12Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"In een prospectief cohort van 480.344 deelnemers uit de UK Biobank werd het samenspel tussen luchtvervuiling (fijnstof, stikstofoxiden) en multimorbiditeit onderzocht in relatie tot het optreden van atriumfibrilleren. De resultaten benadrukken de combinatie van milieubelasting en chronische ziekte als risicofactor.","abstract_original":"<sec><st>Background</st>\n<p>Emerging evidence suggests associations between air pollution, multimorbidity, and atrial fibrillation (AF), but their interplay remains unclear. We evaluated these relationships in a prospective cohort.</p>\n</sec>\n<sec><st>Methods</st>\n<p>We retrieved a total of 480 344 individuals from the UK Biobank. The quantification of air pollutants (particulate matter with a diameter &le;2.5 &mu;m (PM<SUB>2.5</SUB>), particulate matter with a diameter &le;10 &mu;m (PM<SUB>10</SUB>), nitrogen oxides (NO<SUB>x</SUB>) and nitrogen dioxide (NO<SUB>2</SUB>)) was conducted at the geocoded residential locations of each participant. Multimorbidity clusters were determined using latent class analysis using 35 long-term conditions (LTCsc. Three latent classes were identified: non-cardiovascular disease (non-CVD) multimorbidity, mental health multimorbidity and cardiometabolic multimorbidity. These were compared with no LTCs and singular LTCs. Cox models examined the effects of"}