{"id":"21fc60154329","type":"article","url":"https://hartvaat.nl/2026/02/23/nierbescherming-na-harttransplantatie-risicoreductie-en-therapeutische-mogelijkh/","title":"Nierbescherming na harttransplantatie: risicoreductie en therapeutische mogelijkheden","title_en":"Mitigating Risk of Kidney Dysfunction After Heart Transplantation and Therapeutic Approaches.","category":"chronische nierziekte","category_label":"Nierziekte","professions":["cardioloog","internist"],"tags":["acuut-hartfalen","harttransplantatie","hfpef","ijzertekort","niertransplantatie","ventrikelfibrilleren"],"journal":"Circulation. Heart failure","doi":"10.1161/CIRCHEARTFAILURE.125.013747","source_url":"https://doi.org/10.1161/CIRCHEARTFAILURE.125.013747","authors":["Ersilia M DeFilippis","Richard K Cheng","Elena M Donald","Shannon M Dunlay","Lorraine S Evangelista","Forum Kamdar","Prateeti Khazanie","Selma F Mohammed","Ana Rossi","Harriette G C Van Spall","Aradhana Verma","Khadijah Breathett"],"significance":7,"published":"2026-02-23","source_date":"2026-02-23","image":"","kennis":["https://hartvaat.nl/kennis/nierziekte/sglt2-nierbescherming-mechanisme/","https://hartvaat.nl/kennis/farmacologie/sglt2-remmers-farmacologie/"],"congress":"","summary_en":"This Circulation Heart Failure review addressed strategies for mitigating kidney dysfunction after heart transplantation, covering recipient risk factors, perioperative management, and therapeutic approaches to preserve renal function.","created":"2026-07-03T10:25:01Z","updated":"2026-07-03T18:38:11Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Nierdisfunctie na harttransplantatie is geassocieerd met significante morbiditeit en mortaliteit. Dit overzicht in Circulation Heart Failure bespreekt risicofactoren, het toenemende gebruik van mechanische circulatoire ondersteuning en nefroprotectieve strategieën waaronder RAAS-remming en SGLT2-remmers.","abstract_original":"Kidney dysfunction after heart transplantation (HT) is associated with significant morbidity and mortality. Recipient and perioperative factors may all influence the risk of kidney injury. Furthermore, data suggest that the incidence of kidney dysfunction, both acute and chronic, is increasing after the implementation of the United States' 2018 allocation system due to increasing use of temporary mechanical circulatory support and changing recipient characteristics. While data are robust regarding nephroprotective therapies such as renin-angiotensin-aldosterone system inhibition and SGLT2 (sodium-glucose cotransporter 2) inhibitors to minimize the progression of chronic kidney disease in patients with heart failure, data in HT recipients are beginning to emerge. This state-of-the-art review will critically examine the existing literature regarding the epidemiology of kidney dysfunction after HT, mitigation strategies for acute kidney injury and chronic kidney disease, including pharmacotherapeutics, the need for kidney transplantation after HT, and practical next steps for the larger HT community."}