{"id":"9d781e0ea95e","type":"article","url":"https://hartvaat.nl/2026/02/23/verhoogd-activine-a-bij-peripartum-cardiomyopathie-en-tijdens-lv-herstel/","title":"Verhoogd Activine-A bij peripartum cardiomyopathie en tijdens LV-herstel","title_en":"Elevated Activin-A serum levels in patients with acute peripartum cardiomyopathy and during left ventricular recovery.","category":"hartfalen","category_label":"Hartfalen","professions":["cardioloog"],"tags":["cardiomyopathie-gerichte-therapie","peripartum-cardiomyopathie","vrouwen"],"journal":"ESC heart failure","doi":"10.1093/eschf/xvag062","source_url":"https://doi.org/10.1093/eschf/xvag062","authors":["Thomas Gausepohl","Tobias Jonathan Pfeffer","Tobias König","Dominik Berliner","Martina Kasten","Jason Roh","Denise Hilfiker-Kleiner","Johann Bauersachs","Melanie Ricke-Hoch"],"significance":6,"published":"2026-02-23","source_date":"2026-02-23","image":"","kennis":["https://hartvaat.nl/kennis/hartfalen/hartfalen-en-zwangerschap/"],"congress":"","summary_en":"This German PPCM registry study found elevated serum levels of Activin-A, a senescence-associated factor, in patients with acute peripartum cardiomyopathy, identifying a potential biomarker for this pregnancy-associated heart failure.","created":"2026-07-03T10:25:01Z","updated":"2026-07-03T13:24:29Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"In het Duitse PPCM-register werden verhoogde serumspiegels van Activine-A — een senescence-geassocieerde factor — gevonden bij patiënten met acute peripartum cardiomyopathie. De spiegels werden ook gevolgd tijdens linkerventrikel-herstel, wat nieuwe inzichten biedt in de pathofysiologie van deze aandoening.","abstract_original":"AIM: Peripartum cardiomyopathy (PPCM) is an idiopatic form of heart failure occuring in the peripartum phase. Elevated circulating levels of the senescence-associated-secretory-phenotype (SASP) factor Activin-A have been associated with heart failure severity in acute PPCM patients at baseline diagnosis. Here, we investigated Activin-A serum levels in the German PPCM registry in acute PPCM and during left ventricular (LV) recovery. METHODS AND RESULTS: Clinical data including LV ejection fraction (LVEF) and Activin-A serum levels were assessed at initial diagnosis (baseline [BL], ) and during follow-up (FU) at 3 months (M) and 6M in PPCM patients from the German PPCM Registry (n=151, mean age 33±5 years) compared to postpartum healthy controls (n=27, mean age 32±5 years). Activin-A serum levels at BL were elevated (404pg/ml; interquartile range [IQR]: 197-815, n=151) compared to healthy postpartum controls (240 pg/ml, IQR:148-446, n=27; P<0.01) and remained persistently elevated above postpartum healthy controls at 3M (418 pg/ml, IQR: 169-806, n=100) and 6M-FU (520 pg/ml, IQR: 214-1131, n=104). Activin-A levels at BL did not correlate with LVEF (Spearman r=0.10, p=0.2416, n=139), NT-proBNP (r=0.096, p=0.2766, n=131), CRP (r=-0.0008, p= 0.9933; n=110) or PPCM biomarker plasminogen-activator-inhibitor-1 (PAI-1) (r=0.095, p=0.3273, n=109). The majority of PPCM patients showed LV recovery 6M after initial diagnosis, indicated by improved LVEF (PPCM BL: 25%, IQR: 20-33, n=152; 6M-FU: 52% IQR: 45-56, n=128, P<0.0001). Activin-A levels did not differ between full or incomplete LV recovery, or between patients with hypertensive pregnancy disorders. CONCLUSIONS: In PPCM patients from the German PPCM registry Activin-A serum levels were elevated at diagnosis, remained persistently high after 3M- and 6M-FU but were not associated with LV recovery."}