{"id":"fb10fc259655","type":"article","url":"https://hartvaat.nl/2026/02/24/glp-1-agonisten-versus-dpp-4-remmers-en-sglt2-remmers-bij-hartfalenrisico/","title":"GLP-1-agonisten versus DPP-4-remmers en SGLT2-remmers bij hartfalenrisico","title_en":"Risk of Heart Failure Hospitalization for GLP-1 Receptor Agonists Versus DPP-4 Inhibitors or SGLT-2 Inhibitors in Patients With Type 2 Diabetes: A Target Trial Emulation","category":"algemeen","category_label":"Algemeen","professions":["apotheker","cardioloog","internist"],"tags":["canagliflozine","cardiorenal-behandelstrategie","dapagliflozine","empagliflozine","glp1-agonisten","glp1-semaglutide-cardiovasculair","liraglutide","orforglipron","semaglutide","sglt2-remmers","tirzepatide"],"journal":"Circulation","doi":"https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.125.075157","source_url":"https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.125.075157","authors":["Yang Xu"],"significance":8,"published":"2026-02-24","source_date":"2026-02-24","image":"","kennis":["https://hartvaat.nl/kennis/cardiometabool/diabetes-type-1-en-hart/","https://hartvaat.nl/kennis/cardiometabool/diabetes-en-cardiovasculair-risico/"],"congress":"","summary_en":"This target trial emulation using Swedish population data compared GLP-1 receptor agonists with DPP-4 inhibitors and SGLT2 inhibitors for heart failure hospitalization risk in type 2 diabetes, providing real-world comparative effectiveness data for cardiometabolic drug selection.","created":"2026-07-03T10:25:06Z","updated":"2026-07-03T13:24:33Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"In een target trial emulatie met Zweedse populatiedata werden GLP-1-receptoragonisten vergeleken met DPP-4-remmers en SGLT2-remmers voor het risico op ziekenhuisopname wegens hartfalen bij patiënten met diabetes type 2. De studie levert nieuwe inzichten op over de onderlinge positionering van deze middelen.","abstract_original":"BACKGROUND:Novel treatments are needed for the primary and secondary prevention of heart failure in patients with type 2 diabetes, including individuals with and those without a history of heart failure. Conflicting trial evidence exists on whether glucagon-like peptide-1 receptor agonists (GLP-1RAs) reduce the risk of hospitalization for heart failure (HHF) in this broad population and whether this is a class effect or varies by specific agent. Furthermore, their comparative effectiveness against sodium-glucose cotransporter-2 inhibitors (SGLT-2is) is unknown.METHODS:We emulated 2 target trials using population-based health care data from Stockholm, Sweden (2010–2021). Target trial 1 included adult patients with type 2 diabetes who newly initiated GLP-1RA versus dipeptidyl peptidase-4 inhibitors (DPP-4is), and target trial 2 compared GLP-1RA with SGLT-2i. The primary outcome was HHF. Cox regression was used to estimate intention-to-treat hazard ratios, with inverse probability of trea"}