# Multidisciplinaire cardiometabole kliniek: LDL-C-verlaging in de dagelijkse praktijk

*geplaatst 2026-02-24 · Cholesterol · Internal medicine journal · doi 10.1111/imj.70334 · https://hartvaat.nl/2026/02/24/multidisciplinaire-cardiometabole-kliniek-ldl-c-verlaging-in-de-dagelijkse-prakt/*

Real-world data van de eerste 200 patiënten van een multidisciplinaire cardiometabole polikliniek toont effectieve LDL-cholesterolverlaging in de praktijk, met inzet van PCSK9-remmers bij patiënten met FH en cardiovasculaire ziekte die ondanks statinetherapie hun streefwaarden niet bereiken.

## English: Early outcomes from a new multidisciplinary cardiometabolic clinic: real-world experience in lowering low-density lipoprotein cholesterol.

Real-world data from the first 200 patients at a new multidisciplinary cardiometabolic clinic demonstrate effective LDL-cholesterol lowering with PCSK9 inhibitors in patients with FH and cardiovascular disease who fail to reach targets on statins alone.

## Abstract (original, from the publication)

This study presents real-world data on low-density lipoprotein cholesterol (LDL-C) management in the first 200 patients seen at a new multidisciplinary cardiometabolic clinic from January 2023, with follow-up until April 2024. The cohort had a mean ± standard deviation age of 52 ± 14 years, 51% were male, 69 (35%) had familial hypercholesterolaemia and 66 (33%) had cardiovascular disease. Lipid-lowering therapies were escalated in 120 (60%) patients. Median low-density lipoprotein cholesterol level decreased with initiation of evolocumab (69%), inclisiran (56%), statin (45%) and ezetimibe (21%). In patients with a history of statin intolerance, 19 (43%) re-initiated or increased statin dose.

Auteurs: Ying Yi Wendy Yap, Nick S R Lan, Girish Dwivedi, Bu B Yeap, P Gerry Fegan, Krishnamurthy Chikkaveerappa

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Bron: Internal medicine journal, https://doi.org/10.1111/imj.70334. Bijgewerkt 2026-07-03T13:24:25Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.