{"id":"16dd2b509ccc","type":"article","url":"https://hartvaat.nl/2026/02/24/polygene-risicoscores-en-hla-klasse-ii-als-biomarkers-voor-corticosteroidrespons/","title":"Polygene risicoscores en HLA klasse II als biomarkers voor corticosteroïdrespons bij nefrotisch syndroom","title_en":"Polygenic Risk Scores and HLA Class II Variants are Biomarkers of Corticosteroid Response in Childhood Nephrotic Syndrome","category":"chronische nierziekte","category_label":"Nierziekte","professions":["internist"],"tags":["polygene-risicoscore"],"journal":"Kidney International","doi":"https://www.kidney-international.org/article/S0085-2538(26)00134-1/fulltext","source_url":"https://doi.org/https://www.kidney-international.org/article/S0085-2538(26)00134-1/fulltext","authors":["Tiffany Tu","Alejandro Ochoa","Amika Sood","Ashley Dabrik","Megan Chryst-Stangl","Brandon Lane","Guanghong Wu","Frank Donovan","Ursula Harper","Settara Chandrasekharappa","Christopher Esezobor","Adaobi Solarin","David Hooper","Christine Sethna","Sandra Amaral","Mahmoud Kallash","Michelle Rheault","Priya Verghese","Vikas Dharnidharka","Eloise Salmon","Patricia Weng","Tarak Srivastava","Michael E. Seifert","Cozumel Pruette","David Selewski","Keisha Gibson","Tracy Hunley","Asiri Abeyagunawardena","Shenal Thalgahagoda","Arvind Bagga","Aditi Sinha","Nicholas Webb","Larry Greenbaum","Ali Gharavi","Krzysztof Kiryluk","Matthias Kretzler","Lisa Guay-Woodford","Simone Sanna-Cherchi","Agnieszka Bierzynska","Ania Koziell","Gavin Welsh","Moin Saleem","Charles Rotimi","Eileen Chambers","Cliburn Chan","CureGN Consortium","PNRC Glomerular Disease Group","CIBMTR/NMDP Consortium","Annette Jackson","Adebowale Adeyemo","Rasheed Gbadegesin"],"significance":5,"published":"2026-02-24","source_date":"2026-02-24","image":"","kennis":["https://hartvaat.nl/kennis/farmacologie/antiaritmica-farmacologie/","https://hartvaat.nl/kennis/cardiometabool/bloedsuikerdoelen-cardiovasculair/"],"congress":"","summary_en":"This study identified polygenic risk scores and HLA class II variants as biomarkers for predicting corticosteroid response in childhood nephrotic syndrome, potentially enabling treatment stratification at initial presentation.","created":"2026-07-03T10:25:16Z","updated":"2026-07-03T13:24:43Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Nefrotisch syndroom bij kinderen wordt geclassificeerd op basis van respons op corticosteroïden. Er zijn echter geen klinische biomarkers om de respons te voorspellen. Deze studie onderzocht polygene risicoscores en HLA klasse II-varianten als voorspellers.","abstract_original":"Nephrotic syndrome (NS), a common glomerular disease in children, is classified based on response to corticosteroid therapy as either steroid-sensitive nephrotic syndrome (SSNS), or steroid-resistant nephrotic syndrome (SRNS). However, there are no current reliable predictors of therapy response at initial clinical presentation."}