{"id":"6e6ee2a164d4","type":"article","url":"https://hartvaat.nl/2026/02/24/renale-denervatie-verbetert-leververvetting-bij-hypertensieve-patienten-met-meta/","title":"Renale denervatie verbetert leververvetting bij hypertensieve patiënten met metabool syndroom","title_en":"Renal Denervation Improves Hepatic Steatosis in Hypertensive Patients With Metabolic Syndrome","category":"hartfalen","category_label":"Hartfalen","professions":["cardioloog","huisarts","internist"],"tags":["anemie-ckd","bloeddrukbehandeling","cardio-renaal-metabool","cardiorenal-behandelstrategie","diuretica","dubbele-trombocytenremming","fidelity","figaro-dkd","perifeer-vaatlijden","radiance-htn","renale-denervatie","resistente-hypertensie-aldosteronremmers","vrouwen"],"journal":"Hypertension","doi":"https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.26601","source_url":"https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.26601","authors":["Mert Tokcan"],"significance":7,"published":"2026-02-24","source_date":"2026-02-24","image":"","kennis":["https://hartvaat.nl/kennis/farmacologie/betablokkers-cardiale-indicaties/","https://hartvaat.nl/kennis/hartfalen/wat-is-hartfalen/"],"congress":"","summary_en":"This study showed that renal denervation improves hepatic steatosis in hypertensive patients with metabolic syndrome, demonstrating that sympathetic nervous system modulation has metabolic benefits beyond blood pressure reduction.","created":"2026-07-03T10:24:58Z","updated":"2026-07-03T18:38:09Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Bij patiënten met ongecontroleerde hypertensie en cardiometabole comorbiditeiten verbeterde renale denervatie niet alleen de bloeddruk, maar ook non-invasieve markers van leververvetting (HSI en FLI). Deze studie suggereert dat sympathische modulatie via RDN ook hepatische effecten heeft.","abstract_original":"Hypertension, Volume 83, Issue 4, Page e26601, April 1, 2026. BACKGROUND:Sympathetic overactivity is associated with hepatic steatosis. Renal denervation (RDN) is an approved treatment for uncontrolled hypertension through sympathetic modulation; however, its hepatic effects are unknown. This study aimed to assess the effects of RDN on noninvasive tests for hepatic steatosis.METHODS:This single-center study included patients with uncontrolled hypertension and cardiometabolic comorbidities undergoing RDN (n=32) or a sham procedure (n=10). Noninvasive tests for hepatic steatosis, including the hepatic steatosis index (HSI) and fatty liver index (FLI), were calculated at baseline and follow-up visits. An external cohort from the UK Biobank was used to validate the correlation between proton density fat fraction magnetic resonance imaging scans of the liver and these surrogates.RESULTS:Compared with the control group, RDN significantly reduced HSI at 3 months (0.4±0.5 versus −1.3±0.3;P=0.0"}