# Renale denervatie verbetert leververvetting bij hypertensieve patiënten met metabool syndroom

*geplaatst 2026-02-24 · Hartfalen · Hypertension · doi https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.26601 · https://hartvaat.nl/2026/02/24/renale-denervatie-verbetert-leververvetting-bij-hypertensieve-patienten-met-meta/*

Bij patiënten met ongecontroleerde hypertensie en cardiometabole comorbiditeiten verbeterde renale denervatie niet alleen de bloeddruk, maar ook non-invasieve markers van leververvetting (HSI en FLI). Deze studie suggereert dat sympathische modulatie via RDN ook hepatische effecten heeft.

## English: Renal Denervation Improves Hepatic Steatosis in Hypertensive Patients With Metabolic Syndrome

This study showed that renal denervation improves hepatic steatosis in hypertensive patients with metabolic syndrome, demonstrating that sympathetic nervous system modulation has metabolic benefits beyond blood pressure reduction.

## Abstract (original, from the publication)

Hypertension, Volume 83, Issue 4, Page e26601, April 1, 2026. BACKGROUND:Sympathetic overactivity is associated with hepatic steatosis. Renal denervation (RDN) is an approved treatment for uncontrolled hypertension through sympathetic modulation; however, its hepatic effects are unknown. This study aimed to assess the effects of RDN on noninvasive tests for hepatic steatosis.METHODS:This single-center study included patients with uncontrolled hypertension and cardiometabolic comorbidities undergoing RDN (n=32) or a sham procedure (n=10). Noninvasive tests for hepatic steatosis, including the hepatic steatosis index (HSI) and fatty liver index (FLI), were calculated at baseline and follow-up visits. An external cohort from the UK Biobank was used to validate the correlation between proton density fat fraction magnetic resonance imaging scans of the liver and these surrogates.RESULTS:Compared with the control group, RDN significantly reduced HSI at 3 months (0.4±0.5 versus −1.3±0.3;P=0.0

Auteurs: Mert Tokcan

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Bron: Hypertension, https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.26601. Bijgewerkt 2026-07-03T18:38:09Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.