{"id":"d51166f93759","type":"article","url":"https://hartvaat.nl/2026/02/25/klotho-in-het-distale-nefron-reguleert-calciumreabsorptie-maar-niet-fosfaathomeo/","title":"Klotho in het distale nefron reguleert calciumreabsorptie maar niet fosfaathomeostase","title_en":"Klotho in the kidney distal convolution regulates urinary Klotho excretion and kidney calcium reabsorption, but not phosphate homeostasis.","category":"chronische nierziekte","category_label":"Nierziekte","professions":["internist"],"tags":[],"journal":"Kidney International","doi":"https://www.kidney-international.org/article/S0085-2538(26)00142-0/fulltext","source_url":"https://doi.org/https://www.kidney-international.org/article/S0085-2538(26)00142-0/fulltext","authors":["Laurent Bourqui","Adisa Trnjanin","Klaudia Kopper","Dominique Loffing-Cueni","Zsuzsa Radvanyi","Artyom Karpovich","Tara Rahimi","Rui Santos","Agnieszka Wengi","Johanne Pastor","Orson W. Moe","Johannes Loffing","Ganesh Pathare"],"significance":4,"published":"2026-02-25","source_date":"2026-02-25","image":"","kennis":["https://hartvaat.nl/kennis/farmacologie/aldosteron-en-raas-farmacologie/"],"congress":"","summary_en":"This study demonstrates that Klotho in the kidney distal convolution regulates urinary Klotho excretion and calcium reabsorption but does not directly participate in phosphate homeostasis, refining understanding of Klotho biology.","created":"2026-07-03T10:25:16Z","updated":"2026-07-03T13:24:42Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Klotho is een co-receptor voor FGF-23 en komt voor in membraangebonden en oplosbare vorm. Dit onderzoek toont aan dat Klotho in de distale tubulus de urinaire Klotho-excretie en renale calciumreabsorptie reguleert, maar geen directe rol speelt in de fosfaathomeostase.","abstract_original":"Klotho acts as a coreceptor for the phosphaturic hormone fibroblast growth factor-23 (FGF-23) and exists in both a membrane-bound and a soluble form (sKlotho) found in blood and urine. Klotho protein is moderately expressed in kidney proximal tubule and more abundant in the distal convolution (DC), which includes the distal convoluted tubule (DCT) and connecting tubule (CNT). However, the function of Klotho in the DC, particularly its role in sKlotho release and regulation of mineral metabolism, remains unclear."}