{"id":"c3351651f5b3","type":"article","url":"https://hartvaat.nl/2026/02/25/langetermijnincidentie-van-atriumfibrilleren-en-het-risico-op-beroerte-20-jaar-f/","title":"Langetermijnincidentie van atriumfibrilleren en het risico op beroerte: 20 jaar follow-up (INTERGENE)","title_en":"Long-term incidence of atrial fibrillation and cardiovascular outcomes in men and women with sinus rhythm: a 20-year follow-up of the INTERGENE population-based cohort","category":"algemeen","category_label":"Algemeen","professions":["cardioloog","huisarts"],"tags":["atriale-cardiomyopathie"],"journal":"Open Heart","doi":"http://openheart.bmj.com/cgi/content/short/13/1/e003944?rss=1","source_url":"https://doi.org/http://openheart.bmj.com/cgi/content/short/13/1/e003944?rss=1","authors":["Viktorisson","A.","Khatib","I. A.","Bashir","M.","Nyberg","F.","Lissner","L.","Thelle","D. S."],"significance":6,"published":"2026-02-25","source_date":"2026-02-25","image":"","kennis":["https://hartvaat.nl/kennis/cardiometabool/diabetes-type-1-en-hart/","https://hartvaat.nl/kennis/cardiometabool/obesitas-en-hart/"],"congress":"","summary_en":"Estimates of long-term atrial fibrillation (AF) incidence in people with sinus rhythm are limited. In the Swedish population-based INTERGENE study, 2,967 AF-free participants (mean age 50.7, 53% female) were followed for over 20 years. During 53,447 person-years, 12.0% developed AF (incidence 6.66 per 1,000 person-years). At 20 years, cumulative AF incidence (accounting for competing death) was 2.1% in those younger than 45 at baseline, 13.3% at 45-65 and 29.5% above 65; men had higher incidence in all age groups. Incident AF was associated with ischaemic stroke (HR 1.80) and overall cardiovascular disease (HR 2.07). AF is thus a common long-term outcome, especially in older adults and men, associated with increased stroke and cardiovascular risk — arguing for age- and sex-specific risk stratification and early AF detection.","created":"2026-07-03T10:32:24Z","updated":"2026-07-03T18:39:24Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Schattingen van de langetermijnincidentie van atriumfibrilleren (AF) bij mensen met een sinusritme zijn beperkt. In de Zweedse populatiestudie INTERGENE werden 2.967 AF-vrije deelnemers (gemiddeld 50,7 jaar, 53% vrouw) ruim 20 jaar gevolgd. Tijdens 53.447 persoonsjaren ontwikkelde 12,0% AF (incidentie 6,66 per 1.000 persoonsjaren). Na 20 jaar was de cumulatieve AF-incidentie (gecorrigeerd voor concurrerend overlijden) 2,1% bij wie bij aanvang jonger dan 45 jaar was, 13,3% bij 45-65 jaar en 29,5% boven de 65 jaar; mannen hadden in alle leeftijdsgroepen een hogere incidentie. Nieuw AF was geassocieerd met een ischemische beroerte (HR 1,80) en met hart- en vaatziekten in het algemeen (HR 2,07). AF is dus een veelvoorkomende langetermijnuitkomst, vooral bij ouderen en mannen, en gaat gepaard met een verhoogd risico op beroerte en hart- en vaatziekten — wat pleit voor leeftijd- en geslachtsspecifieke risico-inschatting en vroege AF-detectie.","abstract_original":"<sec><st>Background</st>\n<p>Estimates of long-term atrial fibrillation (AF) incidence in individuals with sinus rhythm are limited. This study investigated age-stratified and sex-stratified long-term incidence of AF in individuals with baseline sinus rhythm and no history of AF, and examined associations between AF, ischaemic stroke and overall cardiovascular disease (CVD).</p>\n</sec>\n<sec><st>Methods</st>\n<p>Participants were recruited to the population-based Interplay Between Genetic Susceptibility and External Factors cohort, initiated in western Sweden (2001&ndash;2004). Follow-up of incident diagnoses and mortality continued through national registers until 31 December 2022. Cumulative incidence of AF was calculated accounting for the competing risk of death. Cox regression models assessed associations between AF as a time-varying exposure, incident ischaemic stroke and overall CVD, adjusting for confounding.</p>\n</sec>\n<sec><st>Results</st>\n<p>2967 AF-free participants were included (mean age 50.7&plusmn;13.4 years; 52.9% female). During 53 447 person-years of follow-up (median 20.1 years), 356 (12.0%) developed AF (incidence rate 6.66 per 1000 person-years). At 20 years, the cumulative incidence of AF accounting for competing risk of death was 2.1% (&lt;45 years at baseline), 13.3% (45&ndash;65 years) and 29.5% (&gt;65 years). Men had a higher incidence than women in all age groups. Incident AF was associated with ischaemic stroke (HR 1.80, 95% CI 1.19 to 2.72) and overall CVD (HR 2.07, 95% CI 1.60 to 2.68).</p>\n</sec>\n<sec><st>Conclusions</st>\n<p>AF was a common long-term outcome, particularly among older adults and men, and was associated with subsequent stroke and CVD. Age-specific and sex-specific risk stratification may inform targeted follow-up and early AF detection.</p>\n</sec>"}