{"id":"0237351507d7","type":"article","url":"https://hartvaat.nl/2026/02/26/hiv-infectie-hangt-onafhankelijk-samen-met-meer-en-kwetsbaardere-halsslagaderpla/","title":"Hiv-infectie hangt onafhankelijk samen met meer en kwetsbaardere halsslagaderplaques","title_en":"HIV infection is independently associated with carotid plaque burden and echogenic characteristics","category":"algemeen","category_label":"Algemeen","professions":["cardioloog","huisarts","internist"],"tags":[],"journal":"Open Heart","doi":"http://openheart.bmj.com/cgi/content/short/13/1/e003853?rss=1","source_url":"https://doi.org/http://openheart.bmj.com/cgi/content/short/13/1/e003853?rss=1","authors":["Li","X.","Liu","L.","Chen","J.","Cao","J.","Wang","Z.","Qi","T.","Sun","J.","Yang","J.","Xu","S.","Song","W.","Shao","Y.","Chen","Y.","Tang","Y.","Wang","J.","Wang","L.","Huang","J.","Wang","K.","Sun","M.","Jin","Y.","Zeng","Z.","Zhao","Z.","Zhang","R.","Ding","Y.","Shen","Y."],"significance":5,"published":"2026-02-26","source_date":"2026-02-26","image":"","kennis":["https://hartvaat.nl/kennis/cardiometabool/diabetes-type-1-en-hart/","https://hartvaat.nl/kennis/cardiometabool/diabetes-en-cardiovasculair-risico/"],"congress":"","summary_en":"People with HIV are at increased cardiovascular risk, but data from Asian populations are limited. In this cross-sectional study (Shanghai; 1,390 people with HIV and 1,390 age- and sex-matched people without HIV, aged ≥40), carotid ultrasonography assessed plaque presence and characteristics. Plaques were more common in people with HIV (45.3% vs 37.5%), as were echo-lucent (vulnerable) plaques (21.1% vs 18.0%); they also more often had three or more plaques and greater maximum plaque thickness. After adjustment for age, sex and dyslipidaemia, HIV remained independently associated with plaques (aOR 1.45) and echo-lucent plaques (aOR 1.24), strongest in men and younger participants. HIV infection is thus associated with accelerated atherosclerosis beyond traditional risk factors — supporting routine cardiovascular risk assessment and early prevention in people with HIV.","created":"2026-07-03T10:32:24Z","updated":"2026-07-03T13:31:21Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Mensen met hiv hebben een verhoogd risico op hart- en vaatziekten, maar gegevens uit Aziatische populaties zijn beperkt. In deze cross-sectionele studie (Shanghai; 1.390 mensen met hiv en 1.390 op leeftijd en geslacht gematchte mensen zonder hiv, ≥40 jaar) werd met halsslagader-echografie de aanwezigheid en aard van plaques onderzocht. Plaques kwamen vaker voor bij mensen met hiv (45,3% vs. 37,5%), evenals echo-arme (kwetsbare) plaques (21,1% vs. 18,0%); zij hadden ook vaker drie of meer plaques en een grotere maximale plaquedikte. Na correctie voor leeftijd, geslacht en dyslipidemie bleef hiv onafhankelijk geassocieerd met plaques (aOR 1,45) en echo-arme plaques (aOR 1,24), het sterkst bij mannen en jongere deelnemers. Hiv-infectie gaat dus gepaard met versnelde atherosclerose buiten de klassieke risicofactoren om — wat pleit voor routinematige cardiovasculaire risico-evaluatie en vroege preventie bij mensen met hiv.","abstract_original":"<sec><st>Background</st>\n<p>People living with HIV (PWH) are at increased risk of cardiovascular disease; however, evidence from Asian populations remains limited. We evaluated the prevalence and characteristics of carotid plaques among PWH and people without HIV (PWoH) in China to examine the impact of HIV infection on subclinical atherosclerosis.</p>\n</sec>\n<sec><st>Methods</st>\n<p>In this cross-sectional study conducted at the Shanghai Public Health Clinical Center, China, we enrolled 1390 PWH and 1390 age-frequency and sex-frequency matched PWoH aged 40 years or older. Carotid ultrasonography was used to assess the presence, number and echogenicity of carotid plaques.</p>\n</sec>\n<sec><st>Results</st>\n<p>The prevalence of carotid plaques was significantly higher in PWH than in PWoH (45.3% vs 37.5%, p&lt;0.001), and the prevalence of echo-lucent plaques was also higher (21.1% vs 18.0%, p=0.045). Among participants with carotid plaques, PWH were more likely to have three or more plaques (35.8% vs 21.2%, p&lt;0.001) and a greater maximum plaque thickness (2.0 mm vs 1.9 mm; p=0.026). After adjustment for age, sex and dyslipidaemia, HIV infection remained independently associated with increased odds of carotid plaques (adjusted OR (aOR)=1.45; 95% CI 1.23 to 1.70) and echo-lucent plaques (aOR=1.24; 95% CI 1.02 to 1.50). Associations were strongest among men and younger participants. No HIV-related clinical factors were significantly associated with carotid plaque presence.</p>\n</sec>\n<sec><st>Conclusion</st>\n<p>HIV infection is independently associated with an increased carotid plaque burden and echo-lucent plaque features, suggesting accelerated atherosclerosis beyond traditional risk factors. These findings support routine cardiovascular risk assessment and early preventive strategies in PWH.</p>\n</sec>"}